{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Robles-Murguia M"],"funding":["NICHD NIH HHS","NIA NIH HHS","Glenn Foundation for Medical Research","National Institute on Aging of the National Institutes of Health","American Federation for Aging Research","American Parkinson Disease Association","Hartwell Foundation","ALSAC","Ellison Medical Foundation"],"pagination":["37-52"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6938663"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(1-2)"],"pubmed_abstract":["In animals, the brain regulates feeding behavior in response to local energy demands of peripheral tissues, which secrete orexigenic and anorexigenic hormones. Although skeletal muscle is a key peripheral tissue, it remains unknown whether muscle-secreted hormones regulate feeding. In <i>Drosophila</i>, we found that <i>decapentaplegic</i> (<i>dpp</i>), the homolog of human bone morphogenetic proteins BMP2 and BMP4, is a muscle-secreted factor (a myokine) that is induced by nutrient sensing and that circulates and signals to the brain. Muscle-restricted dpp RNAi promotes foraging and feeding initiation, whereas <i>dpp</i> overexpression reduces it. This regulation of feeding by muscle-derived Dpp stems from modulation of brain <i>tyrosine hydroxylase</i> (<i>TH</i>) expression and dopamine biosynthesis. Consistently, Dpp receptor signaling in dopaminergic neurons regulates <i>TH</i> expression and feeding initiation via the downstream transcriptional repressor Schnurri. Moreover, pharmacologic modulation of TH activity rescues the changes in feeding initiation due to modulation of <i>dpp</i> expression in muscle. These findings indicate that muscle-to-brain endocrine signaling mediated by the myokine Dpp regulates feeding behavior."],"journal":["Genes & development"],"pubmed_title":["Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis."],"pmcid":["PMC6938663"],"funding_grant_id":["U54 HD083211","R56 AG063806","R01AG055532","R56AG063806","R01 AG055532"],"pubmed_authors":["Finkelstein D","Fan Y","Rao D","Xu B","Demontis F","Robles-Murguia M"],"additional_accession":[]},"is_claimable":false,"name":"Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis.","description":"In animals, the brain regulates feeding behavior in response to local energy demands of peripheral tissues, which secrete orexigenic and anorexigenic hormones. Although skeletal muscle is a key peripheral tissue, it remains unknown whether muscle-secreted hormones regulate feeding. In <i>Drosophila</i>, we found that <i>decapentaplegic</i> (<i>dpp</i>), the homolog of human bone morphogenetic proteins BMP2 and BMP4, is a muscle-secreted factor (a myokine) that is induced by nutrient sensing and that circulates and signals to the brain. Muscle-restricted dpp RNAi promotes foraging and feeding initiation, whereas <i>dpp</i> overexpression reduces it. This regulation of feeding by muscle-derived Dpp stems from modulation of brain <i>tyrosine hydroxylase</i> (<i>TH</i>) expression and dopamine biosynthesis. Consistently, Dpp receptor signaling in dopaminergic neurons regulates <i>TH</i> expression and feeding initiation via the downstream transcriptional repressor Schnurri. Moreover, pharmacologic modulation of TH activity rescues the changes in feeding initiation due to modulation of <i>dpp</i> expression in muscle. These findings indicate that muscle-to-brain endocrine signaling mediated by the myokine Dpp regulates feeding behavior.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2024-02-15T17:23:05.498Z","creation":"2020-07-04T07:18:46Z"},"accession":"S-EPMC6938663","cross_references":{"pubmed":["31831628"],"doi":["10.1101/gad.329110.119"]}}