{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ogita Y"],"funding":["Takahashi Industrial and Economic Research Foundation","Grant-in-Aid for Scientific Research, Japan Society for the Promotion of Science"],"pagination":["100757"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6941857"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Animal sex-determining genes, which bifurcate for female and male development, are diversified even among closely related species. Most of these genes emerged independently from various sex-related genes during species diversity as neofunctionalization-type genes. However, the common mechanisms of this divergent evolution remain poorly understood. Here, we compared the molecular evolution of two sex-determining genes, the medaka dmy and the clawed frog dm-W, which independently evolved from the duplication of the transcription factor-encoding masculinization gene dmrt1. Interestingly, we detected parallel amino acid substitutions, from serine (S) to threonine (T), on the DNA-binding domains of both ancestral DMY and DM-W, resulting from positive selection. Two types of DNA-protein binding "],"journal":["iScience"],"pubmed_title":["Parallel Evolution of Two dmrt1-Derived Genes, dmy and dm-W, for Vertebrate Sex Determination."],"pmcid":["PMC6941857"],"funding_grant_id":["18K06389","22132003"],"pubmed_authors":["Mawaribuchi S","Yoneda S","Oota H","Katsumura T","Watanabe G","Nakasako K","Ogita Y","Tamura K","Ito M","Matsuda M","Takamatsu N"],"additional_accession":[]},"is_claimable":false,"name":"Parallel Evolution of Two dmrt1-Derived Genes, dmy and dm-W, for Vertebrate Sex Determination.","description":"Animal sex-determining genes, which bifurcate for female and male development, are diversified even among closely related species. Most of these genes emerged independently from various sex-related genes during species diversity as neofunctionalization-type genes. However, the common mechanisms of this divergent evolution remain poorly understood. Here, we compared the molecular evolution of two sex-determining genes, the medaka dmy and the clawed frog dm-W, which independently evolved from the duplication of the transcription factor-encoding masculinization gene dmrt1. Interestingly, we detected parallel amino acid substitutions, from serine (S) to threonine (T), on the DNA-binding domains of both ancestral DMY and DM-W, resulting from positive selection. Two types of DNA-protein binding ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-18T15:34:10.592Z","creation":"2025-04-07T02:17:02.652Z"},"accession":"S-EPMC6941857","cross_references":{"pubmed":["31884166"],"doi":["10.1016/j.isci.2019.100757"]}}