biostudies-literatureWang JScience and Technology Commission of Shanghai MunicipalityShanghai Medical Discipline of Key Programs for General SurgeryFoundation of Shanghai Science and Technology CommitteeNational Natural Science Foundation of ChinaJianFeng Project of XuHui Provincial Commission of Health and Family Planning219-228https://www.ebi.ac.uk/biostudies/studies/S-EPMC6942443biostudies-literatureUnknown111(1)Use of immune index is a new potential approach for cancer classification and prediction. To investigate the status and clinical effect of immune index in gallbladder cancer (GBC), 238 GBC patients from Zhongshan Hospital affiliated to Fudan University were involved in the present study, including 113 patients in a training set and 125 patients in a validation set. Five immune cells (macrophages, neutrophils, regulatory T cells, cytotoxic T cells and mast cells) were selected based on a literature review and the immune index for each patient was calculated using the LASSO regression. A low immune index (<1) was defined as immunotype A and a high immune index (≥1) was defined as immunotype B. The 5-year overall survival rate for immunotype A was higher than that for immunotype B in the traiCancer scienceLow immune index correlates with favorable prognosis but with reduced benefit from chemotherapy in gallbladder cancer.PMC6942443164119520008160063081872352SHXH2017032017ZZ02007Liu HWang CChen LSuo TWang JShi XLi MNi XBo XShen SWang YLuo RLu PXin YNan LfalseLow immune index correlates with favorable prognosis but with reduced benefit from chemotherapy in gallbladder cancer.Use of immune index is a new potential approach for cancer classification and prediction. To investigate the status and clinical effect of immune index in gallbladder cancer (GBC), 238 GBC patients from Zhongshan Hospital affiliated to Fudan University were involved in the present study, including 113 patients in a training set and 125 patients in a validation set. Five immune cells (macrophages, neutrophils, regulatory T cells, cytotoxic T cells and mast cells) were selected based on a literature review and the immune index for each patient was calculated using the LASSO regression. A low immune index (<1) was defined as immunotype A and a high immune index (≥1) was defined as immunotype B. The 5-year overall survival rate for immunotype A was higher than that for immunotype B in the trai2020-01-01T00:00:00Z2020 Jan2025-04-19T08:54:44.102Z2020-05-22T07:16:16ZS-EPMC69424433172908810.1111/cas.14239