biostudies-literatureUnknown7(1)Samayoa BIntrahealth International and Ministry of health in GuatemalaAIDS Health FoundationGlobal Action Fund for Fungal Infections and JYLAG<h4>Background</h4>A Diagnostic Laboratory Hub (DLH) was set up in Guatemala to provide opportunistic infection (OI) diagnosis for people with HIV (PWH).<h4>Methods</h4>Patients newly presenting for HIV, PWH not receiving antiretrovirals (ARVs) for >90 days but returned to care (Return/Restart), and PWH on ARVs with symptoms of OIs (ARV treatment) were prospectively included. Screening for tuberculosis, nontuberculous mycobacteria (NTM), histoplasmosis, and cryptococcosis was done. Samples were couriered to the DLH, and results were transmitted electronically. Demographic, diagnostic results, disease burden, treatment, and follow-up to 180 days were analyzed.<h4>Results</h4>In 2017, 1953 patients were included, 923 new HIV infections (an estimated 44% of all new HIV infections in GuatemalaOpen forum infectious diseasesofz534https://www.ebi.ac.uk/biostudies/studies/S-EPMC6942459biostudies-literatureThe Diagnostic Laboratory Hub: A New Health Care System Reveals the Incidence and Mortality of Tuberculosis, Histoplasmosis, and Cryptococcosis of PWH in Guatemala.PMC6942459Gonzalez ECArathoon ESamayoa BAlastruey-Izquierdo AQuinonez M GAde Leon LRSMOrtiz Barrientos BGuzman BMendez Andrade AMRodriguez-Tudela JLPerez JCDenning DW“Fungired”Lopez Perez OEGomez Alcazar ALMoller AAguirre LBonilla OMercado DSajche Aguilar GReyes Munoz VAMedina NCuyuch Sontay GOMazariegos LCFong Araujo MLLau-Bonilla DContreras Marin AVfalseThe Diagnostic Laboratory Hub: A New Health Care System Reveals the Incidence and Mortality of Tuberculosis, Histoplasmosis, and Cryptococcosis of PWH in Guatemala.<h4>Background</h4>A Diagnostic Laboratory Hub (DLH) was set up in Guatemala to provide opportunistic infection (OI) diagnosis for people with HIV (PWH).<h4>Methods</h4>Patients newly presenting for HIV, PWH not receiving antiretrovirals (ARVs) for >90 days but returned to care (Return/Restart), and PWH on ARVs with symptoms of OIs (ARV treatment) were prospectively included. Screening for tuberculosis, nontuberculous mycobacteria (NTM), histoplasmosis, and cryptococcosis was done. Samples were couriered to the DLH, and results were transmitted electronically. Demographic, diagnostic results, disease burden, treatment, and follow-up to 180 days were analyzed.<h4>Results</h4>In 2017, 1953 patients were included, 923 new HIV infections (an estimated 44% of all new HIV infections in Guatemala2020-01-01T00:00:00Z2020 Jan2025-05-29T21:38:02.724Z2025-05-29T21:38:02.724ZS-EPMC69424593191571510.1093/ofid/ofz534