{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2019"],"submitter":["Borchert S"],"pubmed_abstract":["<h4>Background</h4>Malignant pleural mesothelioma (MPM) is a rare, predominantly asbestos-related and biologically highly aggressive tumor associated with a dismal prognosis. Multimodal therapy consisting of platinum-based chemotherapy is the treatment of choice. The reasons underlying the rather poor efficacy of platinum compounds remain largely unknown. Kinase activity might influence cellular response to these regimens.<h4>Materials and methods</h4>For this exploratory study, we screened MPM cell lines (NCI-H2452, NCI-H2052, and MSTO-211H) differing in response to cisplatin and benign control fibroblasts (MRC-5) for overall phosphorylation patterns as well as kinase activity with respect to cellular response to cisplatin-based therapeutics. We analysed the cell lines for cellular kinase"],"journal":["Journal of oncology"],"pagination":["2902985"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6942867"],"repository":["biostudies-literature"],"pubmed_title":["Screening of Pleural Mesothelioma Cell Lines for Kinase Activity May Identify New Mechanisms of Therapy Resistance in Patients Receiving Platin-Based Chemotherapy."],"pmcid":["PMC6942867"],"pubmed_authors":["Hegedus B","Mairinger E","Aigner C","Herold T","Eberhardt WEE","Wohlschlaeger J","Hager T","Wessolly M","Mairinger FD","Bankfalvi A","Borchert S","Walter RFH","Suckrau PM","Schmid KW"],"additional_accession":[]},"is_claimable":false,"name":"Screening of Pleural Mesothelioma Cell Lines for Kinase Activity May Identify New Mechanisms of Therapy Resistance in Patients Receiving Platin-Based Chemotherapy.","description":"<h4>Background</h4>Malignant pleural mesothelioma (MPM) is a rare, predominantly asbestos-related and biologically highly aggressive tumor associated with a dismal prognosis. Multimodal therapy consisting of platinum-based chemotherapy is the treatment of choice. The reasons underlying the rather poor efficacy of platinum compounds remain largely unknown. Kinase activity might influence cellular response to these regimens.<h4>Materials and methods</h4>For this exploratory study, we screened MPM cell lines (NCI-H2452, NCI-H2052, and MSTO-211H) differing in response to cisplatin and benign control fibroblasts (MRC-5) for overall phosphorylation patterns as well as kinase activity with respect to cellular response to cisplatin-based therapeutics. We analysed the cell lines for cellular kinase","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-04-15T13:20:51.138Z","creation":"2025-05-29T22:04:55.266Z"},"accession":"S-EPMC6942867","cross_references":{"pubmed":["31929796"],"doi":["10.1155/2019/2902985"]}}