biostudies-literatureUnknown9(1)Tran B<h4>Background</h4>Metastatic germ cell tumor (mGCT) patients receiving chemotherapy have increased risk of life-threatening venous thromboembolism (VTE). Identifying VTE risk factors may guide thromboprophylaxis in this highly curable population.<h4>Methods</h4>Data were collected from mGCT patients receiving first-line platinum-based chemotherapy at 22 centers. Predefined variables included International Germ Cell Cancer Collaborative Group (IGCCCG) risk classification, long-axis diameter of largest retroperitoneal lymph node (RPLN), Khorana score, and use of indwelling vascular access device (VAD). VTE occurring at baseline, during chemotherapy and within 90 days, was analyzed.<h4>Results</h4>Data from 1135 patients were collected. Median age was 31 years (range 10-74). IGCCCG risk was Cancer medicine116-124https://www.ebi.ac.uk/biostudies/studies/S-EPMC6943085biostudies-literatureLarge retroperitoneal lymphadenopathy and increased risk of venous thromboembolism in patients receiving first-line chemotherapy for metastatic germ cell tumors: A study by the global germ cell cancer group (G3).PMC6943085Gonzalez-Billalabeitia EBrito MHermanns TKwan EMReid ASeidel CTran BAmir ERuiz-Morales JMTryakin AFlechon ARumyantsev ABedard PLOttaviano MKitson RCheng TBokemeyer CCastellano DPalmieri GPatrikidou AHamid AAFankhauser CGarcia Del Muro XHeng DYCfalseLarge retroperitoneal lymphadenopathy and increased risk of venous thromboembolism in patients receiving first-line chemotherapy for metastatic germ cell tumors: A study by the global germ cell cancer group (G3).<h4>Background</h4>Metastatic germ cell tumor (mGCT) patients receiving chemotherapy have increased risk of life-threatening venous thromboembolism (VTE). Identifying VTE risk factors may guide thromboprophylaxis in this highly curable population.<h4>Methods</h4>Data were collected from mGCT patients receiving first-line platinum-based chemotherapy at 22 centers. Predefined variables included International Germ Cell Cancer Collaborative Group (IGCCCG) risk classification, long-axis diameter of largest retroperitoneal lymph node (RPLN), Khorana score, and use of indwelling vascular access device (VAD). VTE occurring at baseline, during chemotherapy and within 90 days, was analyzed.<h4>Results</h4>Data from 1135 patients were collected. Median age was 31 years (range 10-74). IGCCCG risk was 2020-01-01T00:00:00Z2020 Jan2025-05-29T21:27:13.029Z2025-05-29T21:27:13.029ZS-EPMC69430853171565010.1002/cam4.2674