{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["81(12)"],"submitter":["Ueda K"],"pubmed_abstract":["Here, we describe the clinical and histopathological characteristics of a malignant peripheral nerve sheath tumor (MPNST) extending from the dorsal subcutis to the periphery of the spine in a female guinea pig aged 3 years 7 months. The patient presented with pleural and blood-like pericardial effusion and died. The tumor had invaded the spine and the surrounding muscles and had grown in hypercellular and hypocellular arrangements of round, broad-spindle, and elongated-spindle cells. We observed a fascicular growth pattern, nuclear palisading, and perivascular accumulations of cells that responded positively to anti-S100, sox10, and CD56 antibodies. This is the first report of a MPSNT in a guinea pig."],"journal":["The Journal of veterinary medical science"],"pagination":["1859-1862"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6943309"],"repository":["biostudies-literature"],"pubmed_title":["A case of a malignant peripheral nerve sheath tumor in a guinea pig."],"pmcid":["PMC6943309"],"pubmed_authors":["Ueda K","Ueda A","Ozaki K"],"additional_accession":[]},"is_claimable":false,"name":"A case of a malignant peripheral nerve sheath tumor in a guinea pig.","description":"Here, we describe the clinical and histopathological characteristics of a malignant peripheral nerve sheath tumor (MPNST) extending from the dorsal subcutis to the periphery of the spine in a female guinea pig aged 3 years 7 months. The patient presented with pleural and blood-like pericardial effusion and died. The tumor had invaded the spine and the surrounding muscles and had grown in hypercellular and hypocellular arrangements of round, broad-spindle, and elongated-spindle cells. We observed a fascicular growth pattern, nuclear palisading, and perivascular accumulations of cells that responded positively to anti-S100, sox10, and CD56 antibodies. This is the first report of a MPSNT in a guinea pig.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2024-02-15T21:48:54.839Z","creation":"2020-05-22T07:28:04Z"},"accession":"S-EPMC6943309","cross_references":{"pubmed":["31645521"],"doi":["10.1292/jvms.19-0464"]}}