{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mengsteab PY"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","NIAMS NIH HHS"],"pagination":["e0227181"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6946545"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["A poly (l-lactic) acid bioengineered anterior cruciate ligament (ACL) matrix has previously demonstrated the ability to support tissue regeneration in a rabbit ACL reconstruction model. The matrix was designed for optimal bone and ligament regeneration by developing a matrix with differential pore sizes in its bone and ligament compartments. Building upon past success, we designed a new bioengineered ACL matrix that is easier to install and can be used with endobutton fixation during ACL reconstruction. To achieve this, a new braiding procedure was developed to allow the matrix to be folded in half, making two-limbs, while maintaining its bone and ligament compartments. The osteointegration of the matrix with and without bone morphogenetic protein 2 (BMP-2) supplementation was evaluated in"],"journal":["PloS one"],"pubmed_title":["Evaluation of a bioengineered ACL matrix's osteointegration with BMP-2 supplementation."],"pmcid":["PMC6946545"],"funding_grant_id":["DP1 AR068147","R01AR063698","R01 AR063698"],"pubmed_authors":["Mengsteab PY","Nair LS","Vella AT","Badon M","Conroy P","Kan HM","Laurencin CT","Otsuka T"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of a bioengineered ACL matrix's osteointegration with BMP-2 supplementation.","description":"A poly (l-lactic) acid bioengineered anterior cruciate ligament (ACL) matrix has previously demonstrated the ability to support tissue regeneration in a rabbit ACL reconstruction model. The matrix was designed for optimal bone and ligament regeneration by developing a matrix with differential pore sizes in its bone and ligament compartments. Building upon past success, we designed a new bioengineered ACL matrix that is easier to install and can be used with endobutton fixation during ACL reconstruction. To achieve this, a new braiding procedure was developed to allow the matrix to be folded in half, making two-limbs, while maintaining its bone and ligament compartments. The osteointegration of the matrix with and without bone morphogenetic protein 2 (BMP-2) supplementation was evaluated in","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-05-31T22:40:30.537Z","creation":"2025-05-31T22:40:30.537Z"},"accession":"S-EPMC6946545","cross_references":{"pubmed":["31910231"],"doi":["10.1371/journal.pone.0227181"]}}