{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":45,"searchCount":0},"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Biancari F"],"pubmed_abstract":["<h4>Background</h4>The outcome after weaning from postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO) is poor. In this study, we investigated the prognostic impact of arterial lactate levels at the time of weaning from postcardiotomy VA.<h4>Methods</h4>This analysis included 338 patients from the multicenter PC-ECMO registry with available data on arterial lactate levels at weaning from VA-ECMO.<h4>Results</h4>Arterial lactate levels at weaning from VA-ECMO (adjusted OR 1.426, 95%CI 1.157-1.758) was an independent predictor of hospital mortality, and its best cutoff values was 1.6 mmol/L (<1.6 mmol/L, 26.2% vs. ≥ 1.6 mmol/L, 45.0%; adjusted OR 2.489, 95%CI 1.374-4.505). When 261 patients with arterial lactate at VA-ECMO weaning ≤2.0 mmol/L were analyzed, a cutoff of arterial lactate of 1.4 mmol/L for prediction of hospital mortality was identified (<1.4 mmol/L, 24.2% vs. ≥1.4 mmol/L, 38.5%, <i>p</i> = 0.014). Among 87 propensity score-matched pairs, hospital mortality was significantly higher in patients with arterial lactate ≥1.4 mmol/L (39.1% vs. 23.0%, <i>p</i> = 0.029) compared to those with lower arterial lactate.<h4>Conclusions</h4>Increased arterial lactate levels at the time of weaning from postcardiotomy VA-ECMO increases significantly the risk of hospital mortality. Arterial lactate may be useful in guiding optimal timing of VA-ECMO weaning."],"journal":["Journal of clinical medicine"],"pagination":["E2218"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6947236"],"repository":["biostudies-literature"],"pubmed_title":["Prognostic Significance of Arterial Lactate Levels at Weaning from Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation."],"pmcid":["PMC6947236"],"pubmed_authors":["Pol M","Ruggieri VG","Mariscalco G","Dalen M","Lechiancole A","Fux T","Loforte A","Jonsson K","Spadaccio C","Perrotti A","Saeed D","Zipfel S","Juvonen T","Pettinari M","Bounader K","Dell'Aquila AM","Welp H","Gatti G","Fiore A","Mogianos K","Biancari F","Settembre N","Alkhamees K","Lichtenberg A","El Dean Z"],"view_count":["45"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic Significance of Arterial Lactate Levels at Weaning from Postcardiotomy Venoarterial Extracorporeal Membrane Oxygenation.","description":"<h4>Background</h4>The outcome after weaning from postcardiotomy venoarterial extracorporeal membrane oxygenation (VA-ECMO) is poor. In this study, we investigated the prognostic impact of arterial lactate levels at the time of weaning from postcardiotomy VA.<h4>Methods</h4>This analysis included 338 patients from the multicenter PC-ECMO registry with available data on arterial lactate levels at weaning from VA-ECMO.<h4>Results</h4>Arterial lactate levels at weaning from VA-ECMO (adjusted OR 1.426, 95%CI 1.157-1.758) was an independent predictor of hospital mortality, and its best cutoff values was 1.6 mmol/L (<1.6 mmol/L, 26.2% vs. ≥ 1.6 mmol/L, 45.0%; adjusted OR 2.489, 95%CI 1.374-4.505). When 261 patients with arterial lactate at VA-ECMO weaning ≤2.0 mmol/L were analyzed, a cutoff of arterial lactate of 1.4 mmol/L for prediction of hospital mortality was identified (<1.4 mmol/L, 24.2% vs. ≥1.4 mmol/L, 38.5%, <i>p</i> = 0.014). Among 87 propensity score-matched pairs, hospital mortality was significantly higher in patients with arterial lactate ≥1.4 mmol/L (39.1% vs. 23.0%, <i>p</i> = 0.029) compared to those with lower arterial lactate.<h4>Conclusions</h4>Increased arterial lactate levels at the time of weaning from postcardiotomy VA-ECMO increases significantly the risk of hospital mortality. Arterial lactate may be useful in guiding optimal timing of VA-ECMO weaning.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2024-11-20T17:25:24.301Z","creation":"2020-05-22T07:51:03Z"},"accession":"S-EPMC6947236","cross_references":{"pubmed":["31847464"],"doi":["10.3390/jcm8122218"]}}