{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Till P"],"funding":["Austrian Science Fund FWF"],"pagination":["47-61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6948969"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Long non-coding RNAs (lncRNAs) are crucial factors acting on regulatory processes in eukaryotes. Recently, for the first time in a filamentous fungus, the lncRNA <i>HAX1</i> was characterized in the ascomycete <i>Trichoderma reesei</i>. In industry, this fungus is widely applied for the high-yield production of cellulases. The lncRNA <i>HAX1</i> was reported to influence the expression of cellulase-encoding genes; interestingly, this effect is dependent on the presence of its most abundant length. Clearly, <i>HAX1</i> acts in association with a set of well-described transcription factors to regulate gene expression. In this study, we attempted to elucidate the regulatory strategy of <i>HAX1</i> and its interactions with the major transcriptional activator Xylanase regulator 1 (Xyr1). We de"],"journal":["RNA biology"],"pubmed_title":["Regulation of gene expression by the action of a fungal lncRNA on a transactivator."],"pmcid":["PMC6948969"],"funding_grant_id":["P 26618"],"pubmed_authors":["Yaver D","Till P","Mach-Aigner AR","Mach RL","Derntl C","Kiesenhofer DP"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of gene expression by the action of a fungal lncRNA on a transactivator.","description":"Long non-coding RNAs (lncRNAs) are crucial factors acting on regulatory processes in eukaryotes. Recently, for the first time in a filamentous fungus, the lncRNA <i>HAX1</i> was characterized in the ascomycete <i>Trichoderma reesei</i>. In industry, this fungus is widely applied for the high-yield production of cellulases. The lncRNA <i>HAX1</i> was reported to influence the expression of cellulase-encoding genes; interestingly, this effect is dependent on the presence of its most abundant length. Clearly, <i>HAX1</i> acts in association with a set of well-described transcription factors to regulate gene expression. In this study, we attempted to elucidate the regulatory strategy of <i>HAX1</i> and its interactions with the major transcriptional activator Xylanase regulator 1 (Xyr1). We de","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-04T20:45:03.387Z","creation":"2020-05-22T07:45:00Z"},"accession":"S-EPMC6948969","cross_references":{"pubmed":["31517564"],"doi":["10.1080/15476286.2019.1663618"]}}