{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chauvierre C"],"funding":["ANR","FP7 Health"],"pagination":["E699"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6949921"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(12)"],"pubmed_abstract":["The adhesion molecule P-selectin is present on the cell surface of both activated endothelium and activated platelets. The present study describes the pharmaceutical development, safety evaluation, and preclinical efficacy of a micro-dosed radiotracer. The macromolecular nanoscale assembly consisted of a natural compound made of a sulfated fucose-rich polysaccharides (fucoidan) and a radionuclide (technetium-99m) for the detection of P-selectin expression in cardiovascular diseases. After extraction and fractionation from brown seaweeds, the good manufacturing practice (GMP) production of a low molecular weight (LMW) fucoidan of 7 kDa was achieved and full physicochemical characterization was performed. The regulatory toxicology study in rats of the GMP batch of LMW fucoidan revealed no ad"],"journal":["Marine drugs"],"pubmed_title":["Pharmaceutical Development and Safety Evaluation of a GMP-Grade Fucoidan for Molecular Diagnosis of Cardiovascular Diseases."],"pmcid":["PMC6949921"],"funding_grant_id":["FP7-NMP-2012-LARGE-6-309820","ANR-13-LAB1-0005-01"],"pubmed_authors":["Chauvierre C","Rolland L","Chaubet F","Bussi S","Zheng KH","Chollet L","Aid-Launais R","Chahid Y","Le Guludec D","Bonafe R","Rossi S","Stroes ESG","Fulop T","Szebeni J","Dezsi L","Rouzet F","Maire M","Cabella C","Aerts J","Letourneur D"],"additional_accession":[]},"is_claimable":false,"name":"Pharmaceutical Development and Safety Evaluation of a GMP-Grade Fucoidan for Molecular Diagnosis of Cardiovascular Diseases.","description":"The adhesion molecule P-selectin is present on the cell surface of both activated endothelium and activated platelets. The present study describes the pharmaceutical development, safety evaluation, and preclinical efficacy of a micro-dosed radiotracer. The macromolecular nanoscale assembly consisted of a natural compound made of a sulfated fucose-rich polysaccharides (fucoidan) and a radionuclide (technetium-99m) for the detection of P-selectin expression in cardiovascular diseases. After extraction and fractionation from brown seaweeds, the good manufacturing practice (GMP) production of a low molecular weight (LMW) fucoidan of 7 kDa was achieved and full physicochemical characterization was performed. The regulatory toxicology study in rats of the GMP batch of LMW fucoidan revealed no ad","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-04-04T11:07:00.546Z","creation":"2020-05-22T08:00:08Z"},"accession":"S-EPMC6949921","cross_references":{"pubmed":["31842319"],"doi":["10.3390/md17120699"]}}