biostudies-literatureTakahashi KMinistry of Health, Labour and WelfareDaido Welfare FoundationE1131https://www.ebi.ac.uk/biostudies/studies/S-EPMC6950085biostudies-literatureUnknown11(12)Between 2011 and 2018, 518 respiratory adenovirus infections were diagnosed in a pediatric clinic in Shizuoka, Japan. Detection and typing were performed by partial sequencing of both hexon- and fiber-coding regions which identified: adenovirus type 1 (Ad-1, <i>n</i> = 85), Ad-2 (<i>n</i> = 160), Ad-3 (<i>n</i> = 193), Ad-4 (<i>n</i> = 18), Ad-5 (<i>n</i> = 27), Ad-11 (<i>n</i> = 2), Ad-54 (<i>n</i> = 3), and Ad-56 (<i>n</i> = 1). Considering previous reports of the circulation of an endemic recombinant Ad-2, e.g., Ad-89, 100 samples typed as Ad-2 were randomly selected for further molecular typing by sequencing the penton base-coding region. Despite the high nucleotide sequence conservation in the penton base- coding region, 27 samples showed 98% identity to Ad-2. Furthermore, 14 samples VirusesPediatric Infections by <i>Human mastadenovirus C</i> Types 2, 89, and a Recombinant Type Detected in Japan between 2011 and 2018.PMC69500852019-1810110713 and 10110802Gonzalez GHanaoka NKonagaya MFujimoto TOgi MNojiri NKobayashi MTakahashi KCarr MJfalsePediatric Infections by <i>Human mastadenovirus C</i> Types 2, 89, and a Recombinant Type Detected in Japan between 2011 and 2018.Between 2011 and 2018, 518 respiratory adenovirus infections were diagnosed in a pediatric clinic in Shizuoka, Japan. Detection and typing were performed by partial sequencing of both hexon- and fiber-coding regions which identified: adenovirus type 1 (Ad-1, <i>n</i> = 85), Ad-2 (<i>n</i> = 160), Ad-3 (<i>n</i> = 193), Ad-4 (<i>n</i> = 18), Ad-5 (<i>n</i> = 27), Ad-11 (<i>n</i> = 2), Ad-54 (<i>n</i> = 3), and Ad-56 (<i>n</i> = 1). Considering previous reports of the circulation of an endemic recombinant Ad-2, e.g., Ad-89, 100 samples typed as Ad-2 were randomly selected for further molecular typing by sequencing the penton base-coding region. Despite the high nucleotide sequence conservation in the penton base- coding region, 27 samples showed 98% identity to Ad-2. Furthermore, 14 samples 2019-01-01T00:00:00Z2019 Dec2026-04-29T01:49:40.773Z2020-05-22T07:52:04ZS-EPMC69500853181776410.3390/v11121131