biostudies-literatureUnknown11(12)Barasse VIn the mutualisms involving certain pseudomyrmicine ants and different myrmecophytes (i.e., plants sheltering colonies of specialized "plant-ant" species in hollow structures), the ant venom contributes to the host plant biotic defenses by inducing the rapid paralysis of defoliating insects and causing intense pain to browsing mammals. Using integrated transcriptomic and proteomic approaches, we identified the venom peptidome of the plant-ant <i>Tetraponera aethiops</i> (Pseudomyrmecinae). The transcriptomic analysis of its venom glands revealed that 40% of the expressed contigs encoded only seven peptide precursors related to the ant venom peptides from the A-superfamily. Among the 12 peptide masses detected by liquid chromatography-mass spectrometry (LC-MS), nine mature peptide sequencesToxinsE732https://www.ebi.ac.uk/biostudies/studies/S-EPMC6950161biostudies-literatureThe Peptide Venom Composition of the Fierce Stinging Ant <i>Tetraponera aethiops</i> (Formicidae: Pseudomyrmecinae).PMC6950161Barasse VTreilhou MTindo MKenne MBonnafe EDejean ATouchard AKlopp CTene NfalseThe Peptide Venom Composition of the Fierce Stinging Ant <i>Tetraponera aethiops</i> (Formicidae: Pseudomyrmecinae).In the mutualisms involving certain pseudomyrmicine ants and different myrmecophytes (i.e., plants sheltering colonies of specialized "plant-ant" species in hollow structures), the ant venom contributes to the host plant biotic defenses by inducing the rapid paralysis of defoliating insects and causing intense pain to browsing mammals. Using integrated transcriptomic and proteomic approaches, we identified the venom peptidome of the plant-ant <i>Tetraponera aethiops</i> (Pseudomyrmecinae). The transcriptomic analysis of its venom glands revealed that 40% of the expressed contigs encoded only seven peptide precursors related to the ant venom peptides from the A-superfamily. Among the 12 peptide masses detected by liquid chromatography-mass spectrometry (LC-MS), nine mature peptide sequences2019-01-01T00:00:00Z2019 Dec2026-05-05T01:19:41.702Z2020-05-22T07:54:13ZS-EPMC69501613184736810.3390/toxins11120732