{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gourh P"],"funding":["NCATS NIH HHS","NIAMS NIH HHS"],"pagination":["552-562"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6955366"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117(1)"],"pubmed_abstract":["Systemic sclerosis (SSc) is a clinically heterogeneous autoimmune disease characterized by mutually exclusive autoantibodies directed against distinct nuclear antigens. We examined <i>HLA</i> associations in SSc and its autoantibody subsets in a large, newly recruited African American (AA) cohort and among European Americans (EA). In the AA population, the African ancestry-predominant <i>HLA-DRB1</i>*<i>08:04</i> and <i>HLA-DRB1</i>*<i>11:02</i> alleles were associated with overall SSc risk, and the <i>HLA-DRB1</i>*<i>08:04</i> allele was strongly associated with the severe antifibrillarin (AFA) antibody subset of SSc (odds ratio = 7.4). These African ancestry-predominant alleles may help explain the increased frequency and severity of SSc among the AA population. In the EA population, the"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["<i>HLA</i> and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry."],"pmcid":["PMC6955366"],"funding_grant_id":["K23 AR075112","T32 AR048522","UL1 TR003167","K08 AR070285","P60 AR062755","P30 AR070254","P30 AR070155","K01 AR067280"],"pubmed_authors":["Schiopu E","Silver RM","Alexander T","Khanna D","Shah AA","Shriner D","Korman BD","Bernstein EJ","Hsu V","Remmers EF","Boyden SE","Shanmugam VK","Bentley AR","Derk CT","Kafaja S","Mayes MD","Boin F","Mullikin JC","Domsic RT","Varga J","Kolstad KD","Kastner DL","Goldberg A","Criswell LA","Safran SA","Chung L","Jan R","Wigley FM","Steen VD","Ramos PS","Rotimi C","Gladue H","Saketkoo LA","Bridges SL","Trojanowski M","Adeyemo A","Morgan ND","Gourh P","Chandrasekharappa SC","Doumatey A","Steinbach PJ","Gordon JK","Kron B","Medsger TA"],"additional_accession":[]},"is_claimable":false,"name":"<i>HLA</i> and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry.","description":"Systemic sclerosis (SSc) is a clinically heterogeneous autoimmune disease characterized by mutually exclusive autoantibodies directed against distinct nuclear antigens. We examined <i>HLA</i> associations in SSc and its autoantibody subsets in a large, newly recruited African American (AA) cohort and among European Americans (EA). In the AA population, the African ancestry-predominant <i>HLA-DRB1</i>*<i>08:04</i> and <i>HLA-DRB1</i>*<i>11:02</i> alleles were associated with overall SSc risk, and the <i>HLA-DRB1</i>*<i>08:04</i> allele was strongly associated with the severe antifibrillarin (AFA) antibody subset of SSc (odds ratio = 7.4). These African ancestry-predominant alleles may help explain the increased frequency and severity of SSc among the AA population. In the EA population, the","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2026-05-07T07:48:15.294Z","creation":"2020-05-22T07:54:43Z"},"accession":"S-EPMC6955366","cross_references":{"pubmed":["31871193"],"doi":["10.1073/pnas.1906593116"]}}