{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ashikawa Y"],"funding":["the Japan Society for the Promotion of Science KAKENHI"],"pagination":["E156"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6958487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["Neurogenesis is the process by which undifferentiated progenitor cells develop into mature and functional neurons. Defects in neurogenesis are associated with neurodevelopmental and neuropsychiatric disorders; therefore, elucidating the molecular mechanisms underlying neurogenesis can advance our understanding of the pathophysiology of these disorders and facilitate the discovery of novel therapeutic targets. In this study, we performed a comparative transcriptomic analysis to identify common targets of the proneural transcription factors Neurog1/2 and Ascl1 during neurogenesis of human and mouse stem cells. We successfully identified C3orf70 as a novel common target gene of Neurog1/2 and Ascl1 during neurogenesis. Using in situ hybridization, we demonstrated that c3orf70a and c3orf70b, tw"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["C3orf70 Is Involved in Neural and Neurobehavioral Development."],"pmcid":["PMC6958487"],"funding_grant_id":["16K08547, 18K06890, 19K07318"],"pubmed_authors":["Miura K","Nishimura Y","Shiromizu T","Bessho Y","Tanaka T","Adachi Y","Ashikawa Y","Matsui T"],"additional_accession":[]},"is_claimable":false,"name":"C3orf70 Is Involved in Neural and Neurobehavioral Development.","description":"Neurogenesis is the process by which undifferentiated progenitor cells develop into mature and functional neurons. Defects in neurogenesis are associated with neurodevelopmental and neuropsychiatric disorders; therefore, elucidating the molecular mechanisms underlying neurogenesis can advance our understanding of the pathophysiology of these disorders and facilitate the discovery of novel therapeutic targets. In this study, we performed a comparative transcriptomic analysis to identify common targets of the proneural transcription factors Neurog1/2 and Ascl1 during neurogenesis of human and mouse stem cells. We successfully identified C3orf70 as a novel common target gene of Neurog1/2 and Ascl1 during neurogenesis. Using in situ hybridization, we demonstrated that c3orf70a and c3orf70b, tw","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2026-04-30T15:17:11.881Z","creation":"2020-05-22T08:26:42Z"},"accession":"S-EPMC6958487","cross_references":{"pubmed":["31623237"],"doi":["10.3390/ph12040156"]}}