biostudies-literatureAshikawa Ythe Japan Society for the Promotion of Science KAKENHIE156https://www.ebi.ac.uk/biostudies/studies/S-EPMC6958487biostudies-literatureUnknown12(4)Neurogenesis is the process by which undifferentiated progenitor cells develop into mature and functional neurons. Defects in neurogenesis are associated with neurodevelopmental and neuropsychiatric disorders; therefore, elucidating the molecular mechanisms underlying neurogenesis can advance our understanding of the pathophysiology of these disorders and facilitate the discovery of novel therapeutic targets. In this study, we performed a comparative transcriptomic analysis to identify common targets of the proneural transcription factors Neurog1/2 and Ascl1 during neurogenesis of human and mouse stem cells. We successfully identified C3orf70 as a novel common target gene of Neurog1/2 and Ascl1 during neurogenesis. Using in situ hybridization, we demonstrated that c3orf70a and c3orf70b, twPharmaceuticals (Basel, Switzerland)C3orf70 Is Involved in Neural and Neurobehavioral Development.PMC695848716K08547, 18K06890, 19K07318Miura KNishimura YShiromizu TBessho YTanaka TAdachi YAshikawa YMatsui TfalseC3orf70 Is Involved in Neural and Neurobehavioral Development.Neurogenesis is the process by which undifferentiated progenitor cells develop into mature and functional neurons. Defects in neurogenesis are associated with neurodevelopmental and neuropsychiatric disorders; therefore, elucidating the molecular mechanisms underlying neurogenesis can advance our understanding of the pathophysiology of these disorders and facilitate the discovery of novel therapeutic targets. In this study, we performed a comparative transcriptomic analysis to identify common targets of the proneural transcription factors Neurog1/2 and Ascl1 during neurogenesis of human and mouse stem cells. We successfully identified C3orf70 as a novel common target gene of Neurog1/2 and Ascl1 during neurogenesis. Using in situ hybridization, we demonstrated that c3orf70a and c3orf70b, tw2019-01-01T00:00:00Z2019 Oct2026-04-30T15:17:11.881Z2020-05-22T08:26:42ZS-EPMC69584873162323710.3390/ph12040156