biostudies-literatureJoshi PNIEHS NIH HHSNational Institutes of HealthVanderbilt University148-157https://www.ebi.ac.uk/biostudies/studies/S-EPMC6961782biostudies-literatureUnknown75Manganese (Mn) is essential for neuronal health but neurotoxic in excess. Mn levels vary across brain regions and neurodevelopment. While Mn requirements during infanthood and childhood are significantly higher than in adulthood, the relative vulnerability to excess extracellular Mn across human neuronal developmental time and between distinct neural lineages is unknown. Neurological disease is associated with changes in brain Mn homeostasis and pathology associated with Mn neurotoxicity is not uniform across brain regions. For example, mutations associated with Huntington's disease (HD) decrease Mn bioavailability and increase resistance to Mn cytotoxicity in human and mouse striatal neuronal progenitors. Here, we sought to compare the differences in Mn cytotoxicity between control and HDNeurotoxicologyHuntington's disease associated resistance to Mn neurotoxicity is neurodevelopmental stage and neuronal lineage dependent.PMC6961782R01 ES016931R01 ES010563Joshi PAschner MBowman ABIlieva IBodnya CNeely MDfalseHuntington's disease associated resistance to Mn neurotoxicity is neurodevelopmental stage and neuronal lineage dependent.Manganese (Mn) is essential for neuronal health but neurotoxic in excess. Mn levels vary across brain regions and neurodevelopment. While Mn requirements during infanthood and childhood are significantly higher than in adulthood, the relative vulnerability to excess extracellular Mn across human neuronal developmental time and between distinct neural lineages is unknown. Neurological disease is associated with changes in brain Mn homeostasis and pathology associated with Mn neurotoxicity is not uniform across brain regions. For example, mutations associated with Huntington's disease (HD) decrease Mn bioavailability and increase resistance to Mn cytotoxicity in human and mouse striatal neuronal progenitors. Here, we sought to compare the differences in Mn cytotoxicity between control and HD2019-01-01T00:00:00Z2019 Dec2025-04-22T10:37:20.809Z2021-02-20T02:07:24ZS-EPMC69617823154597110.1016/j.neuro.2019.09.007