{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(7)"],"submitter":["Zhang Z"],"pubmed_abstract":["Objective: To detect the serum epithelial growth factor receptor (EGFR) gene mutation status in patients with lung cancer via second-generation sequencing and to analyze its correlations with the clinical features of patients and its therapeutic effects. Methods: A total of 110 patients with non-small cell lung cancer (NSCLC) treated in our hospital were recruited as subjects of our study. The distribution of the EGFR gene mutation in patients was detected via second-generation sequencing and then patients were divided into mutant-type EGFR group (n=37) and wild-type EGFR group (n=73). The clinical features and therapeutic effects were compared between the two groups of patients. Results: A total of 5 kinds of EGFR gene mutation [19del (45.95%), L858R (43.24%), L861Q (5.41%), S768I (2.70%)"],"journal":["International journal of clinical and experimental pathology"],"pagination":["3551-3558"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6962891"],"repository":["biostudies-literature"],"pubmed_title":["Serum EGFR gene mutation status via second-generation sequencing and clinical features of patients with advanced lung cancer."],"pmcid":["PMC6962891"],"pubmed_authors":["Zhang Z","Zhou S"],"additional_accession":[]},"is_claimable":false,"name":"Serum EGFR gene mutation status via second-generation sequencing and clinical features of patients with advanced lung cancer.","description":"Objective: To detect the serum epithelial growth factor receptor (EGFR) gene mutation status in patients with lung cancer via second-generation sequencing and to analyze its correlations with the clinical features of patients and its therapeutic effects. Methods: A total of 110 patients with non-small cell lung cancer (NSCLC) treated in our hospital were recruited as subjects of our study. The distribution of the EGFR gene mutation in patients was detected via second-generation sequencing and then patients were divided into mutant-type EGFR group (n=37) and wild-type EGFR group (n=73). The clinical features and therapeutic effects were compared between the two groups of patients. Results: A total of 5 kinds of EGFR gene mutation [19del (45.95%), L858R (43.24%), L861Q (5.41%), S768I (2.70%)","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-26T16:47:12.233Z","creation":"2020-05-22T08:27:45Z"},"accession":"S-EPMC6962891","cross_references":{"pubmed":["31949733"]}}