biostudies-literatureUnknown7(4)De Francesco MAWe report the first case, to our knowledge, in Italy, of a severe combined immunodeficiency patient with a persistent rotavirus infection due to a vaccine derived strain. Rotavirus was detected by enzyme immunoassays and RT-PCR in stool specimens for five months. The persistent infection was resolved after complete immune reconstitution achieved by hematopoietic stem cell transplantation. This case underlines the importance of neonatal SCID_screening.VaccinesE185https://www.ebi.ac.uk/biostudies/studies/S-EPMC6963346biostudies-literaturePersistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?PMC6963346Schumacher RFDe Francesco MAIaniro GCaruso AGurrieri FVezzoli CMonini MLorenzin GGiliani SfalsePersistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?We report the first case, to our knowledge, in Italy, of a severe combined immunodeficiency patient with a persistent rotavirus infection due to a vaccine derived strain. Rotavirus was detected by enzyme immunoassays and RT-PCR in stool specimens for five months. The persistent infection was resolved after complete immune reconstitution achieved by hematopoietic stem cell transplantation. This case underlines the importance of neonatal SCID_screening.2019-01-01T00:00:00Z2019 Nov2024-02-15T21:53:23.83Z2020-05-22T11:07:16ZS-EPMC69633463174413310.3390/vaccines7040185