{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(1)"],"submitter":["Henrey A"],"funding":["CIHR"],"pubmed_abstract":["BACKGROUND:Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or over-treatment. Our objective was to externally validate Nordic clinical prediction models in Canadian patients with JIA. METHODS:We used data from 513 subjects at the 3-year follow-up from the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcomes were non-achievement of remission, severe disease course, and functional disability. The Nordic models were evaluated exactly as published and after fine-tuning the logistic regression coefficients using multiple data splits of the Canadian cohort. Missing data was handled wit"],"journal":["Arthritis research & therapy"],"pagination":["10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6964007"],"repository":["biostudies-literature"],"pubmed_title":["Validation of prediction models of severe disease course and non-achievement of remission in juvenile idiopathic arthritis part 2: results of the Nordic model in the Canadian cohort."],"pmcid":["PMC6964007"],"pubmed_authors":["Yeung RSM","Haddad E","Silverman E","Lang B","Shiff NJ","Dancey P","Rosenberg AM","Spiegel L","Benseler SM","Dorval J","Jurencak R","Henrey A","Bruns A","Chan M","Feldman BM","Rumsey DG","Barsalou J","Morishita K","Petty RE","Larche M","Watanabe Duffy K","Berard RA","St Cyr C","Gibbon M","Chedeville G","Bolaria R","Turvey SE","Gerhold K","Roth J","Nordal E","Johnson N","Huber AM","Feldman D","ReACCh-Out and NoSPeR Investigators","Cameron B","Tse SM","Duffy CM","LeBlanc C","Guzman J","Stringer E","Scuccimarri R","Tucker LB","Houghton K","Ramsey SE","Levy DM","Schneider R","Campillo S","Cabral DA","Oen K","Chetaille AL","Rypdal M","Miettunen P","Boire G","Laxer RM","Loughin T","Ellsworth J","Gross K","Luca N","Schmeling H","Rypdal V"],"additional_accession":[]},"is_claimable":false,"name":"Validation of prediction models of severe disease course and non-achievement of remission in juvenile idiopathic arthritis part 2: results of the Nordic model in the Canadian cohort.","description":"BACKGROUND:Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or over-treatment. Our objective was to externally validate Nordic clinical prediction models in Canadian patients with JIA. METHODS:We used data from 513 subjects at the 3-year follow-up from the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcomes were non-achievement of remission, severe disease course, and functional disability. The Nordic models were evaluated exactly as published and after fine-tuning the logistic regression coefficients using multiple data splits of the Canadian cohort. Missing data was handled wit","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-26T06:30:56.109Z","creation":"2020-05-22T08:11:13Z"},"accession":"S-EPMC6964007","cross_references":{"pubmed":["31941530"],"doi":["10.1186/s13075-019-2091-8"]}}