biostudies-literatureUnknown22(1)Henrey ACIHRBACKGROUND:Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or over-treatment. Our objective was to externally validate Nordic clinical prediction models in Canadian patients with JIA. METHODS:We used data from 513 subjects at the 3-year follow-up from the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcomes were non-achievement of remission, severe disease course, and functional disability. The Nordic models were evaluated exactly as published and after fine-tuning the logistic regression coefficients using multiple data splits of the Canadian cohort. Missing data was handled witArthritis research & therapy10https://www.ebi.ac.uk/biostudies/studies/S-EPMC6964007biostudies-literatureValidation of prediction models of severe disease course and non-achievement of remission in juvenile idiopathic arthritis part 2: results of the Nordic model in the Canadian cohort.PMC6964007Yeung RSMHaddad ESilverman ELang BShiff NJDancey PRosenberg AMSpiegel LBenseler SMDorval JJurencak RHenrey ABruns AChan MFeldman BMRumsey DGBarsalou JMorishita KPetty RELarche MWatanabe Duffy KBerard RASt Cyr CGibbon MChedeville GBolaria RTurvey SEGerhold KRoth JNordal EJohnson NHuber AMFeldman DReACCh-Out and NoSPeR InvestigatorsCameron BTse SMDuffy CMLeBlanc CGuzman JStringer EScuccimarri RTucker LBHoughton KRamsey SELevy DMSchneider RCampillo SCabral DAOen KChetaille ALRypdal MMiettunen PBoire GLaxer RMLoughin TEllsworth JGross KLuca NSchmeling HRypdal VfalseValidation of prediction models of severe disease course and non-achievement of remission in juvenile idiopathic arthritis part 2: results of the Nordic model in the Canadian cohort.BACKGROUND:Validated clinical prediction models to identify children with poor prognosis at the time of juvenile idiopathic arthritis (JIA) diagnosis would be very helpful for tailoring treatments, and avoiding under- or over-treatment. Our objective was to externally validate Nordic clinical prediction models in Canadian patients with JIA. METHODS:We used data from 513 subjects at the 3-year follow-up from the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort. The predicted outcomes were non-achievement of remission, severe disease course, and functional disability. The Nordic models were evaluated exactly as published and after fine-tuning the logistic regression coefficients using multiple data splits of the Canadian cohort. Missing data was handled wit2020-01-01T00:00:00Z2020 Jan2025-04-26T06:30:56.109Z2020-05-22T08:11:13ZS-EPMC69640073194153010.1186/s13075-019-2091-8