{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["121(12)"],"submitter":["Jesinghaus M"],"pubmed_abstract":["<h4>Background</h4>Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant therapy.<h4>Methods</h4>We evaluated cell nest size and tumour budding activity in 122 post-neoadjuvant ESCC resections, correlated the results with tumour regression groups and patient survival and compared the results with data from primary resected cases as well as pre-therapeutic biopsies.<h4>Results</h4>CDG remained stable when results from pre-therapeutic biopsies and post-therapeutic resections from the same patient were compared. CDG was associated with thera"],"journal":["British journal of cancer"],"pagination":["1050-1057"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6964693"],"repository":["biostudies-literature"],"pubmed_title":["Post-neoadjuvant cellular dissociation grading based on tumour budding and cell nest size is associated with therapy response and survival in oesophageal squamous cell carcinoma."],"pmcid":["PMC6964693"],"pubmed_authors":["Feith M","Jesinghaus M","Boxberg M","Budczies J","Wilhelm D","Schlitter AM","Weichert W","Quante M","Konukiewitz B","Steiger K","Lange S","Dapper H","Friess H","Combs SE","Munch S","Mollenhauer M","Becker KF","Schlag C"],"additional_accession":[]},"is_claimable":false,"name":"Post-neoadjuvant cellular dissociation grading based on tumour budding and cell nest size is associated with therapy response and survival in oesophageal squamous cell carcinoma.","description":"<h4>Background</h4>Cellular Dissociation Grade (CDG) composed of tumour budding and cell nest size has been shown to independently predict prognosis in pre-therapeutic biopsies and primary resections of oesophageal squamous cell carcinoma (ESCC). Here, we aimed to evaluate the prognostic impact of CDG in ESCC after neoadjuvant therapy.<h4>Methods</h4>We evaluated cell nest size and tumour budding activity in 122 post-neoadjuvant ESCC resections, correlated the results with tumour regression groups and patient survival and compared the results with data from primary resected cases as well as pre-therapeutic biopsies.<h4>Results</h4>CDG remained stable when results from pre-therapeutic biopsies and post-therapeutic resections from the same patient were compared. CDG was associated with thera","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Dec","modification":"2025-05-18T11:51:51.332Z","creation":"2025-05-18T11:51:51.332Z"},"accession":"S-EPMC6964693","cross_references":{"pubmed":["31690830"],"doi":["10.1038/s41416-019-0623-2"]}}