biostudies-literatureUnknown10Brisson VLU.S. Department of EnergySiemensConventional methods for extracting rare earth elements from monazite ore require high energy inputs and produce environmentally damaging waste streams. Bioleaching offers a potentially more environmentally friendly alternative extraction process. In order to better understand bioleaching mechanisms, we conducted an exo-metabolomic analysis of a previously isolated rare earth bioleaching fungus from the genus <i>Paecilomyces</i> (GenBank accession numbers KM874779 and KM 874781) to identify contributions of compounds exuded by this fungus to bioleaching activity. Exuded compounds were compared under two growth conditions: growth with monazite ore as the only phosphate source, and growth with a soluble phosphate source (K₂HPO₄) added. Overall metabolite profiling, in cFrontiers in microbiology3008https://www.ebi.ac.uk/biostudies/studies/S-EPMC6971059biostudies-literatureMetabolomic Analysis Reveals Contributions of Citric and Citramalic Acids to Rare Earth Bioleaching by a <i>Paecilomyces</i> Fungus.PMC6971059Brisson VLZhuang WQAlvarez-Cohen LfalseMetabolomic Analysis Reveals Contributions of Citric and Citramalic Acids to Rare Earth Bioleaching by a <i>Paecilomyces</i> Fungus.Conventional methods for extracting rare earth elements from monazite ore require high energy inputs and produce environmentally damaging waste streams. Bioleaching offers a potentially more environmentally friendly alternative extraction process. In order to better understand bioleaching mechanisms, we conducted an exo-metabolomic analysis of a previously isolated rare earth bioleaching fungus from the genus <i>Paecilomyces</i> (GenBank accession numbers KM874779 and KM 874781) to identify contributions of compounds exuded by this fungus to bioleaching activity. Exuded compounds were compared under two growth conditions: growth with monazite ore as the only phosphate source, and growth with a soluble phosphate source (K₂HPO₄) added. Overall metabolite profiling, in c2019-01-01T00:00:00Z20192026-05-07T14:22:19.877Z2020-05-22T08:52:56ZS-EPMC69710593199303710.3389/fmicb.2019.03008