biostudies-literatureGanzevoort WMedical Research Council68-74https://www.ebi.ac.uk/biostudies/studies/S-EPMC6973288biostudies-literatureUnknown55(1)<h4>Objective</h4>To explore the effect on perinatal outcome of different fetal monitoring strategies for early-onset fetal growth restriction (FGR).<h4>Methods</h4>This was a cohort analysis of individual participant data from two European multicenter trials of fetal monitoring methods for FGR: the Growth Restriction Intervention Study (GRIT) and the Trial of Umbilical and Fetal Flow in Europe (TRUFFLE). All women from GRIT (n = 238) and TRUFFLE (n = 503) who were randomized between 26 and 32 weeks' gestation were included. The women were grouped according to intervention and monitoring method: immediate delivery (GRIT) or delayed delivery with monitoring by conventional cardiotocography (CTG) (GRIT), computerized CTG (cCTG) only (GRIT and TRUFFLE) or cCTG and ductus venosus (DV) Doppler Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and GynecologyComparative analysis of 2-year outcomes in GRIT and TRUFFLE trials.PMC6973288G9533539Pernet PJMPapageorghiou ATSchneider KTMvan Roosmalen JLees CKalakoutis GMMarsal KVan Damme MNapolitano RKitzinger SCornette JMJSak PKonje JDe Vries LStewart BO'Hara AThilaganathan BJohal WElliman AFraser RBHughes JThornton JVan Bulck BFlumini CMcCormick DWalker JWalker LTRUFFLE Study GroupSwaminathan Svan Leemhuis ATsitsikas HSaharia EStigter RHNovak-Antolic ZSoothill PMarlowe NByrne DFabris CMani EFerrazzi EGRIT Study GroupMissfelder-Lobos HBosisio PMajor TLobmaier STenore ACBewley SZimmerman AMason GNicocia MRamalho RCerar-Kornhauser LThomas SAbdullah MScudamore IKingdom JDawson AKlenke HMcGhee TBrezinka CFusi LMires GLees CCKai NTonge HMBilardo CMTuffnell DSchlembach DFerretti GManyonda ITParmar MCresswell JMartinelli PRoncaglia NTydeman GNeales KFairlie FMGriffin CValcamonico ABreart GSteel SAEken PTorgeson DArduini DPokorna PHowie PMastritta EGee HField DMurtagh KChurchill DDuvekot JJMarlow NBeattie BSibanda ZKubicka ZGraham MRowsell PRobins JBMacGregor ROstermayer EWolke DKyriakides SValensise HThornton JGFratelli NVisser GHAKarpathios SEHeard MJWelch CRRamsay MGriffiths MMaso GHarpin VWilczynski JHallam PDanielian PJenkinson SDTodros THarrison AYoong AJohnson AHecher KGanzevoort WDerks JBBurton KWolf HFrusca TLevene Mvan Geijn HTariq TRashid MSim TPrefumo FBober SMaresh Mvan der Slikke JWPandey SSengupta BJohanson RPorter NGrant AIbbs PHCameron HArabin BSteer PVasco ELindow SWDiemert AWalkinshaw SAWeinans MJNKilding JfalseComparative analysis of 2-year outcomes in GRIT and TRUFFLE trials.<h4>Objective</h4>To explore the effect on perinatal outcome of different fetal monitoring strategies for early-onset fetal growth restriction (FGR).<h4>Methods</h4>This was a cohort analysis of individual participant data from two European multicenter trials of fetal monitoring methods for FGR: the Growth Restriction Intervention Study (GRIT) and the Trial of Umbilical and Fetal Flow in Europe (TRUFFLE). All women from GRIT (n = 238) and TRUFFLE (n = 503) who were randomized between 26 and 32 weeks' gestation were included. The women were grouped according to intervention and monitoring method: immediate delivery (GRIT) or delayed delivery with monitoring by conventional cardiotocography (CTG) (GRIT), computerized CTG (cCTG) only (GRIT and TRUFFLE) or cCTG and ductus venosus (DV) Doppler 2020-01-01T00:00:00Z2020 Jan2025-04-22T00:21:48.069Z2020-05-22T08:57:12ZS-EPMC69732883112546510.1002/uog.20354