biostudies-literatureUnknown12Ahmed N<h4>Background and rationale</h4>Stroke is considered the most common cause of adult disability. Intensive rehabilitation protocols outperform nonintensive counterparts. The subacute stroke phase represents a potential window to recovery. Virtual reality (VR) has been shown to provide a more stimulating environment, allowing for increased patient compliance. However, the quality of current literature comparing VR with standard therapies is limited. Our aim is to measure the impact of VR versus standard therapy on the recovery of the upper limb motor function in patients with stroke in the early subacute recovery phase.<h4>Method</h4>This is a randomized, controlled trial that will assign 262 patients to tailor-made standard rehabilitation (TMSR) or TMSR plus immersive VR device. The trial Journal of central nervous system disease1179573519899471https://www.ebi.ac.uk/biostudies/studies/S-EPMC6974741biostudies-literatureThe Impact of Rehabilitation-oriented Virtual Reality Device in Patients With Ischemic Stroke in the Early Subacute Recovery Phase: Study Protocol for a Phase III, Single-Blinded, Randomized, Controlled Clinical Trial.PMC6974741Danyi SAhmad UShan MCandido Santos LFouad AGomez-Rojas OAhmed NHassan Hosseyni SFabiano RNassir RMoura de Oliveira Paiva MSCastro-Tejada GToyama MPedrosa Salles LMontanez-Valverde RSarvodelli MZGrochowski RAAnand SHalalau AJacome AMichel JSushea ASaavedra Ruiz AGLinares JMCasteleins WANagi HMauad VAQSanchez ATfalseThe Impact of Rehabilitation-oriented Virtual Reality Device in Patients With Ischemic Stroke in the Early Subacute Recovery Phase: Study Protocol for a Phase III, Single-Blinded, Randomized, Controlled Clinical Trial.<h4>Background and rationale</h4>Stroke is considered the most common cause of adult disability. Intensive rehabilitation protocols outperform nonintensive counterparts. The subacute stroke phase represents a potential window to recovery. Virtual reality (VR) has been shown to provide a more stimulating environment, allowing for increased patient compliance. However, the quality of current literature comparing VR with standard therapies is limited. Our aim is to measure the impact of VR versus standard therapy on the recovery of the upper limb motor function in patients with stroke in the early subacute recovery phase.<h4>Method</h4>This is a randomized, controlled trial that will assign 262 patients to tailor-made standard rehabilitation (TMSR) or TMSR plus immersive VR device. The trial 2020-01-01T00:00:00Z20202025-04-22T00:17:19.333Z2020-05-22T09:17:42ZS-EPMC69747413200982810.1177/1179573519899471