{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["NIA NIH HHS","NIDDK NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Aging","NIMH NIH HHS","NIAMS NIH HHS","NIGMS NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health"],"pagination":["39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6976694"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(1)"],"pubmed_abstract":["Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60-80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites as"],"journal":["Communications biology"],"pubmed_title":["Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis."],"pmcid":["PMC6976694"],"funding_grant_id":["P20 GM109036","R01 AG056504","R01 AR059781","R01 DK115679","P01 AG039355","R01AG056504","U19 AG055373","R01 AR069055","R01 MH107354","R01 MH104680","R01 AG060341","PO1 AG039355","R01 GM109068"],"pubmed_authors":["Mo C","Recker R","Lappe J","Armstrong DW","Deng HW","Brotto M","Bonewald LF","Shen H","Zhao LJ","Lee JT","Bian L","Su KJ","Wang Z","Kukula M"],"additional_accession":[]},"is_claimable":false,"name":"Quantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis.","description":"Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60-80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites as","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2026-05-13T16:04:02.622Z","creation":"2020-05-22T08:58:57Z"},"accession":"S-EPMC6976694","cross_references":{"pubmed":["31969651"],"doi":["10.1038/s42003-020-0766-y"]}}