biostudies-literatureWang ZNIA NIH HHSNIDDK NIH HHSU.S. Department of Health & Human Services | NIH | National Institute on AgingNIMH NIH HHSNIAMS NIH HHSNIGMS NIH HHSU.S. Department of Health & Human Services | National Institutes of Health39https://www.ebi.ac.uk/biostudies/studies/S-EPMC6976694biostudies-literatureUnknown3(1)Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60-80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites asCommunications biologyQuantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis.PMC6976694P20 GM109036R01 AG056504R01 AR059781R01 DK115679P01 AG039355R01AG056504U19 AG055373R01 AR069055R01 MH107354R01 MH104680R01 AG060341PO1 AG039355R01 GM109068Mo CRecker RLappe JArmstrong DWDeng HWBrotto MBonewald LFShen HZhao LJLee JTBian LSu KJWang ZKukula MfalseQuantification of aminobutyric acids and their clinical applications as biomarkers for osteoporosis.Osteoporosis is a highly prevalent chronic aging-related disease that frequently is only detected after fracture. We hypothesized that aminobutyric acids could serve as biomarkers for osteoporosis. We developed a quick, accurate, and sensitive screening method for aminobutyric acid isomers and enantiomers yielding correlations with bone mineral density (BMD) and osteoporotic fracture. In serum, γ-aminobutyric acid (GABA) and (R)-3-aminoisobutyric acid (D-BAIBA) have positive associations with physical activity in young lean women. D-BAIBA positively associated with hip BMD in older individuals without osteoporosis/osteopenia. Lower levels of GABA were observed in 60-80 year old women with osteoporotic fractures. Single nucleotide polymorphisms in seven genes related to these metabolites as2020-01-01T00:00:00Z2020 Jan2026-05-13T16:04:02.622Z2020-05-22T08:58:57ZS-EPMC69766943196965110.1038/s42003-020-0766-y