{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Diling C"],"pubmed_abstract":["Our pre-experiments found that the brain circRNA sequence profiles and gut microbiota in AD-like mice were changed, as circNF1-419 could enhance autophagy to ameliorate senile dementia in AD-like mice, so we conclude that there might some connections between circRNA and gut microbiome. Therefore, we use the over-expressed <i>circNF1-419</i> adeno-associated virus (AAV) animal system with the aim of identifying possible connections. Our results showed that over-expression of circ<i>NF1-419</i> in brain not only influenced the cholinergic system of brain, but also changed the gut microbiota composition as the <i>Candidatus Arthromitus</i>, <i>Lachnospiraceae FCS020 group</i>, <i>Lachnospiraceae UCG-006</i>, and [Eubacterium] <i>xylanophilum group</i>, and the intestinal homeostasis and physi"],"journal":["Aging"],"pagination":["260-287"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6977659"],"repository":["biostudies-literature"],"pubmed_title":["<i>CircNF1-419</i> improves the gut microbiome structure and function in AD-like mice."],"pmcid":["PMC6977659"],"pubmed_authors":["Yinrui G","Xujiang Y","Xiangxiang Z","Yizhen X","Yang BB","Qingping W","Diling C","Ran L","Dongdong W","Yadi L","Ou S","Longkai Q","Xiaocui T","Miao Z"],"additional_accession":[]},"is_claimable":false,"name":"<i>CircNF1-419</i> improves the gut microbiome structure and function in AD-like mice.","description":"Our pre-experiments found that the brain circRNA sequence profiles and gut microbiota in AD-like mice were changed, as circNF1-419 could enhance autophagy to ameliorate senile dementia in AD-like mice, so we conclude that there might some connections between circRNA and gut microbiome. Therefore, we use the over-expressed <i>circNF1-419</i> adeno-associated virus (AAV) animal system with the aim of identifying possible connections. Our results showed that over-expression of circ<i>NF1-419</i> in brain not only influenced the cholinergic system of brain, but also changed the gut microbiota composition as the <i>Candidatus Arthromitus</i>, <i>Lachnospiraceae FCS020 group</i>, <i>Lachnospiraceae UCG-006</i>, and [Eubacterium] <i>xylanophilum group</i>, and the intestinal homeostasis and physi","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-22T00:17:45.983Z","creation":"2020-05-22T09:00:07Z"},"accession":"S-EPMC6977659","cross_references":{"pubmed":["31905172"],"doi":["10.18632/aging.102614"]}}