biostudies-literatureUnknown12(1)Diling COur pre-experiments found that the brain circRNA sequence profiles and gut microbiota in AD-like mice were changed, as circNF1-419 could enhance autophagy to ameliorate senile dementia in AD-like mice, so we conclude that there might some connections between circRNA and gut microbiome. Therefore, we use the over-expressed circNF1-419 adeno-associated virus (AAV) animal system with the aim of identifying possible connections. Our results showed that over-expression of circNF1-419 in brain not only influenced the cholinergic system of brain, but also changed the gut microbiota composition as the Candidatus Arthromitus, Lachnospiraceae FCS020 group, Lachnospiraceae UCG-006, and [Eubacterium] xylanophilum group, and the intestinal homeostasis and physiAging260-287https://www.ebi.ac.uk/biostudies/studies/S-EPMC6977659biostudies-literatureCircNF1-419 improves the gut microbiome structure and function in AD-like mice.PMC6977659Yinrui GXujiang YXiangxiang ZYizhen XYang BBQingping WDiling CRan LDongdong WYadi LOu SLongkai QXiaocui TMiao ZfalseCircNF1-419 improves the gut microbiome structure and function in AD-like mice.Our pre-experiments found that the brain circRNA sequence profiles and gut microbiota in AD-like mice were changed, as circNF1-419 could enhance autophagy to ameliorate senile dementia in AD-like mice, so we conclude that there might some connections between circRNA and gut microbiome. Therefore, we use the over-expressed circNF1-419 adeno-associated virus (AAV) animal system with the aim of identifying possible connections. Our results showed that over-expression of circNF1-419 in brain not only influenced the cholinergic system of brain, but also changed the gut microbiota composition as the Candidatus Arthromitus, Lachnospiraceae FCS020 group, Lachnospiraceae UCG-006, and [Eubacterium] xylanophilum group, and the intestinal homeostasis and physi2020-01-01T00:00:00Z2020 Jan2025-04-22T00:17:45.983Z2020-05-22T09:00:07ZS-EPMC69776593190517210.18632/aging.102614