{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jacobs DM"],"funding":["VA Merit Review","National Centre for Advancing Translational Sciences","NCATS NIH HHS","National Heart, Lung, and Blood Institutes Loan Repayment Program","NHLBI NIH HHS","National Institutes of Health","Merit Review grant from the Department of Veterans Affairs"],"pagination":["ofz546"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6979313"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(1)"],"pubmed_abstract":["<h4>Background</h4>Tracheobronchial colonization by <i>Pseudomonas aeruginosa</i> (<i>PA</i>) has been shown to negatively impact outcomes in cystic fibrosis and bronchiectasis. There is uncertainty whether the same association is prevalent in chronic obstructive pulmonary disease (COPD), especially in the outpatient setting. Our objective was to determine (1) whether <i>PA</i> isolation is associated with mortality and (2) changes in exacerbation and hospitalization rates within a longitudinal cohort of COPD outpatients.<h4>Methods</h4><i>Pseudomonas aeruginosa</i> colonization was ascertained in monthly sputum cultures in a prospective cohort of COPD patients from 1994 to 2014. All-cause mortality was compared between patients who were colonized during their follow-up period (<i>PA</i> <"],"journal":["Open forum infectious diseases"],"pubmed_title":["Impact of <i>Pseudomonas aeruginosa</i> Isolation on Mortality and Outcomes in an Outpatient Chronic Obstructive Pulmonary Disease Cohort."],"pmcid":["PMC6979313"],"funding_grant_id":["L30 HL138791","ULTR001412","1 L30 HL138791-01","KL2 TR001413"],"pubmed_authors":["Ochs-Balcom HM","Jacobs DM","Sethi S","Noyes K","Pu CY","Zhao J","Leung WY","Murphy TF"],"additional_accession":[]},"is_claimable":false,"name":"Impact of <i>Pseudomonas aeruginosa</i> Isolation on Mortality and Outcomes in an Outpatient Chronic Obstructive Pulmonary Disease Cohort.","description":"<h4>Background</h4>Tracheobronchial colonization by <i>Pseudomonas aeruginosa</i> (<i>PA</i>) has been shown to negatively impact outcomes in cystic fibrosis and bronchiectasis. There is uncertainty whether the same association is prevalent in chronic obstructive pulmonary disease (COPD), especially in the outpatient setting. Our objective was to determine (1) whether <i>PA</i> isolation is associated with mortality and (2) changes in exacerbation and hospitalization rates within a longitudinal cohort of COPD outpatients.<h4>Methods</h4><i>Pseudomonas aeruginosa</i> colonization was ascertained in monthly sputum cultures in a prospective cohort of COPD patients from 1994 to 2014. All-cause mortality was compared between patients who were colonized during their follow-up period (<i>PA</i> <","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-27T02:38:38.57Z","creation":"2020-05-22T09:02:29Z"},"accession":"S-EPMC6979313","cross_references":{"pubmed":["31993457"],"doi":["10.1093/ofid/ofz546"]}}