{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin Y"],"funding":["NIBIB NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["4897-4900"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6980340"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(19)"],"pubmed_abstract":["We demonstrate spectroscopic photonic force optical coherence elastography (PF-OCE). Oscillations of microparticles embedded in viscoelastic hydrogels were induced by harmonically modulated optical radiation pressure and measured by phase-sensitive spectral-domain optical coherence tomography. PF-OCE can detect microparticle displacements with pico- to nano-meter sensitivity and millimeter-scale volumetric coverage. With spectroscopic PF-OCE, we quantified viscoelasticity over a broad frequency range from 1 Hz to 7 kHz, revealing rich microstructural dynamics of polymer networks across multiple microrheological regimes. Reconstructed frequency-dependent loss moduli of polyacrylamide hydrogels were observed to follow a general power scaling law G''∼ω0.75, consistent with that of semiflexible polymer networks. Spectroscopic PF-OCE provides an all-optical approach to microrheological studies with high sensitivity and high spatiotemporal resolution, and could be especially beneficial for time-lapse and volumetric mechanical characterization of viscoelastic materials."],"journal":["Optics letters"],"pubmed_title":["Spectroscopic photonic force optical coherence elastography."],"pmcid":["PMC6980340"],"funding_grant_id":["R01 GM132823","R01GM132823","R21EB024747","R21 EB024747"],"pubmed_authors":["Leartprapun N","Lin Y","Adie SG"],"additional_accession":[]},"is_claimable":false,"name":"Spectroscopic photonic force optical coherence elastography.","description":"We demonstrate spectroscopic photonic force optical coherence elastography (PF-OCE). Oscillations of microparticles embedded in viscoelastic hydrogels were induced by harmonically modulated optical radiation pressure and measured by phase-sensitive spectral-domain optical coherence tomography. PF-OCE can detect microparticle displacements with pico- to nano-meter sensitivity and millimeter-scale volumetric coverage. With spectroscopic PF-OCE, we quantified viscoelasticity over a broad frequency range from 1 Hz to 7 kHz, revealing rich microstructural dynamics of polymer networks across multiple microrheological regimes. Reconstructed frequency-dependent loss moduli of polyacrylamide hydrogels were observed to follow a general power scaling law G''∼ω0.75, consistent with that of semiflexible polymer networks. Spectroscopic PF-OCE provides an all-optical approach to microrheological studies with high sensitivity and high spatiotemporal resolution, and could be especially beneficial for time-lapse and volumetric mechanical characterization of viscoelastic materials.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Oct","modification":"2025-04-04T13:32:03.812Z","creation":"2025-02-19T04:02:51.358Z"},"accession":"S-EPMC6980340","cross_references":{"pubmed":["31568470"],"doi":["10.1364/OL.44.004897","10.1364/ol.44.004897"]}}