{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":54,"searchCount":0},"additional":{"submitter":["Phipps EJT"],"funding":["NIGMS NIH HHS"],"pagination":["6807-6811"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6980370"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["141(17)"],"pubmed_abstract":["We have developed a Rh(III)-catalyzed diastereoselective [2+1] annulation onto allylic alcohols initiated by alkenyl C-H activation of N-enoxyphthalimides to furnish substituted cyclopropyl-ketones. Notably, the traceless oxyphthalimide handle serves three functions: directing C-H activation, oxidation of Rh(III), and, collectively with the allylic alcohol, in directing cyclopropanation to control diastereoselectivity. Allylic alcohols are shown to be highly reactive olefin coupling partners leading to a directed diastereoselective cyclopropanation reaction, providing products not accessible by other routes."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Rh(III)-Catalyzed C-H Activation-Initiated Directed Cyclopropanation of Allylic Alcohols."],"pmcid":["PMC6980370"],"funding_grant_id":["R01 GM080442"],"pubmed_authors":["Phipps EJT","Rovis T"],"view_count":["54"],"additional_accession":[]},"is_claimable":false,"name":"Rh(III)-Catalyzed C-H Activation-Initiated Directed Cyclopropanation of Allylic Alcohols.","description":"We have developed a Rh(III)-catalyzed diastereoselective [2+1] annulation onto allylic alcohols initiated by alkenyl C-H activation of N-enoxyphthalimides to furnish substituted cyclopropyl-ketones. Notably, the traceless oxyphthalimide handle serves three functions: directing C-H activation, oxidation of Rh(III), and, collectively with the allylic alcohol, in directing cyclopropanation to control diastereoselectivity. Allylic alcohols are shown to be highly reactive olefin coupling partners leading to a directed diastereoselective cyclopropanation reaction, providing products not accessible by other routes.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 May","modification":"2020-10-29T10:07:08Z","creation":"2020-10-02T07:13:06Z"},"accession":"S-EPMC6980370","cross_references":{"pubmed":["30998324"],"doi":["10.1021/jacs.9b02156"]}}