{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Altendahl M"],"funding":["American Heart Association","National Institute of Neurological Disorders and Stroke","NIA NIH HHS","NINDS NIH HHS","National Institute on Aging"],"pagination":["e0227835"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6980497"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Chronic systemic sterile inflammation is implicated in the pathogenesis of cerebrovascular disease and white matter injury. Non-invasive blood markers for risk stratification and dissection of inflammatory molecular substrates in vivo are lacking. We sought to identify whether an interconnected network of inflammatory biomarkers centered on IL-18 and all previously associated with white matter lesions could detect overt and antecedent white matter changes in two populations at risk for cerebral small vessel disease. In a cohort of 167 older adults (mean age: 76, SD 7.1, 83 females) that completed a cognitive battery, physical examination, and blood draw in parallel with MR imaging including DTI, we measured cerebral white matter hyperintensities (WMH) and free water (FW). Concurrently, ser"],"journal":["PloS one"],"pubmed_title":["An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury."],"pmcid":["PMC6980497"],"funding_grant_id":["UH3NS100608","UH3 NS100608","P30 AG062422","T32 AG023481","16GRNT31080021","RF1 AG032289","R01 AG032289","AG062422","T35 AG026736","#15CRP22900006","AG010129","R01 AG048234","P30 AG010129","UH2 NS100608"],"pubmed_authors":["Elahi F","Kakarla V","Elashoff D","Singh B","Walters S","Leng M","Kramer JH","You M","Maillard P","Wolf A","Xiao G","Fox E","Cotter D","Hinman JD","Harvey D","Azizkhanian I","Altendahl M","Sheth SA","Decarli C"],"additional_accession":[]},"is_claimable":false,"name":"An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury.","description":"Chronic systemic sterile inflammation is implicated in the pathogenesis of cerebrovascular disease and white matter injury. Non-invasive blood markers for risk stratification and dissection of inflammatory molecular substrates in vivo are lacking. We sought to identify whether an interconnected network of inflammatory biomarkers centered on IL-18 and all previously associated with white matter lesions could detect overt and antecedent white matter changes in two populations at risk for cerebral small vessel disease. In a cohort of 167 older adults (mean age: 76, SD 7.1, 83 females) that completed a cognitive battery, physical examination, and blood draw in parallel with MR imaging including DTI, we measured cerebral white matter hyperintensities (WMH) and free water (FW). Concurrently, ser","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-22T20:18:57.115Z","creation":"2020-05-22T09:22:44Z"},"accession":"S-EPMC6980497","cross_references":{"pubmed":["31978079"],"doi":["10.1371/journal.pone.0227835"]}}