biostudies-literatureAltendahl MAmerican Heart AssociationNational Institute of Neurological Disorders and StrokeNIA NIH HHSNINDS NIH HHSNational Institute on Aginge0227835https://www.ebi.ac.uk/biostudies/studies/S-EPMC6980497biostudies-literatureUnknown15(1)Chronic systemic sterile inflammation is implicated in the pathogenesis of cerebrovascular disease and white matter injury. Non-invasive blood markers for risk stratification and dissection of inflammatory molecular substrates in vivo are lacking. We sought to identify whether an interconnected network of inflammatory biomarkers centered on IL-18 and all previously associated with white matter lesions could detect overt and antecedent white matter changes in two populations at risk for cerebral small vessel disease. In a cohort of 167 older adults (mean age: 76, SD 7.1, 83 females) that completed a cognitive battery, physical examination, and blood draw in parallel with MR imaging including DTI, we measured cerebral white matter hyperintensities (WMH) and free water (FW). Concurrently, serPloS oneAn IL-18-centered inflammatory network as a biomarker for cerebral white matter injury.PMC6980497UH3NS100608UH3 NS100608P30 AG062422T32 AG02348116GRNT31080021RF1 AG032289R01 AG032289AG062422T35 AG026736#15CRP22900006AG010129R01 AG048234P30 AG010129UH2 NS100608Elahi FKakarla VElashoff DSingh BWalters SLeng MKramer JHYou MMaillard PWolf AXiao GFox ECotter DHinman JDHarvey DAzizkhanian IAltendahl MSheth SADecarli CfalseAn IL-18-centered inflammatory network as a biomarker for cerebral white matter injury.Chronic systemic sterile inflammation is implicated in the pathogenesis of cerebrovascular disease and white matter injury. Non-invasive blood markers for risk stratification and dissection of inflammatory molecular substrates in vivo are lacking. We sought to identify whether an interconnected network of inflammatory biomarkers centered on IL-18 and all previously associated with white matter lesions could detect overt and antecedent white matter changes in two populations at risk for cerebral small vessel disease. In a cohort of 167 older adults (mean age: 76, SD 7.1, 83 females) that completed a cognitive battery, physical examination, and blood draw in parallel with MR imaging including DTI, we measured cerebral white matter hyperintensities (WMH) and free water (FW). Concurrently, ser2020-01-01T00:00:00Z20202025-04-22T20:18:57.115Z2020-05-22T09:22:44ZS-EPMC69804973197807910.1371/journal.pone.0227835