{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Semova I"],"funding":["NCATS NIH HHS","American Heart Association Established Investigator Award","National Institute of Health National Heart, Lung, and Blood Institute","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","NCRR NIH HHS","NHLBI NIH HHS","American Diabetes Association","NIH/NCRR","Juvenile Diabetes Research Foundation Ltd"],"pagination":["940-946"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6980756"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(6)"],"pubmed_abstract":["<h4>Background</h4>To optimize treatment and prevent cardiovascular disease in subjects with type 1 diabetes, it is important to determine how cholesterol metabolism changes with type 1 diabetes.<h4>Objective</h4>The objective of the study was to compare plasma levels of campesterol and β-sitosterol, markers of cholesterol absorption, as well as lathosterol, a marker of cholesterol synthesis, in youth with and without type 1 diabetes.<h4>Methods</h4>Serum samples were obtained from adolescent subjects with type 1 diabetes (n = 175, mean age 15.2 years, mean duration of diabetes 8.2 years) and without diabetes (n = 74, mean age 15.4 years). Campesterol, β-sitosterol, and lathosterol, were measured using targeted liquid chromatography tandem mass spectrometry, compared between groups, and correlated with the available cardiometabolic variables.<h4>Results</h4>Campesterol and β-sitosterol levels were 30% higher in subjects with type 1 diabetes and positively correlated with hemoglobin A1c levels. In contrast, lathosterol levels were 20% lower in subjects with type 1 diabetes and positively correlated with triglycerides, body mass index, and systolic blood pressure.<h4>Conclusion</h4>Plasma markers suggest that cholesterol absorption is increased, whereas cholesterol synthesis is decreased in adolescent subjects with type 1 diabetes. Further studies to address the impact of these changes on the relative efficacy of cholesterol absorption and synthesis inhibitors in subjects with type 1 diabetes are urgently needed."],"journal":["Journal of clinical lipidology"],"pubmed_title":["Type 1 diabetes is associated with an increase in cholesterol absorption markers but a decrease in cholesterol synthesis markers in a young adult population."],"pmcid":["PMC6980756"],"funding_grant_id":["5K12-DK-094721-04","T32 DK007260","11-2007-694","P30 DK116074","R01-HL-109650","R01 HL109650","UL1 TR002535","K23 DK075360","P30 DK040561","UL1 RR025780","DK075360"],"pubmed_authors":["Semova I","Levenson AE","Krawczyk J","Khoury PR","Bullock K","Clish CB","Dolan LM","Kimball TR","Biddinger SB","Shah AS","Urbina EM","Williams KA","Wadwa RP","Maahs DM","Bishop FK","de Ferranti SD"],"additional_accession":[]},"is_claimable":false,"name":"Type 1 diabetes is associated with an increase in cholesterol absorption markers but a decrease in cholesterol synthesis markers in a young adult population.","description":"<h4>Background</h4>To optimize treatment and prevent cardiovascular disease in subjects with type 1 diabetes, it is important to determine how cholesterol metabolism changes with type 1 diabetes.<h4>Objective</h4>The objective of the study was to compare plasma levels of campesterol and β-sitosterol, markers of cholesterol absorption, as well as lathosterol, a marker of cholesterol synthesis, in youth with and without type 1 diabetes.<h4>Methods</h4>Serum samples were obtained from adolescent subjects with type 1 diabetes (n = 175, mean age 15.2 years, mean duration of diabetes 8.2 years) and without diabetes (n = 74, mean age 15.4 years). Campesterol, β-sitosterol, and lathosterol, were measured using targeted liquid chromatography tandem mass spectrometry, compared between groups, and correlated with the available cardiometabolic variables.<h4>Results</h4>Campesterol and β-sitosterol levels were 30% higher in subjects with type 1 diabetes and positively correlated with hemoglobin A1c levels. In contrast, lathosterol levels were 20% lower in subjects with type 1 diabetes and positively correlated with triglycerides, body mass index, and systolic blood pressure.<h4>Conclusion</h4>Plasma markers suggest that cholesterol absorption is increased, whereas cholesterol synthesis is decreased in adolescent subjects with type 1 diabetes. Further studies to address the impact of these changes on the relative efficacy of cholesterol absorption and synthesis inhibitors in subjects with type 1 diabetes are urgently needed.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Nov - Dec","modification":"2024-11-14T01:00:22.072Z","creation":"2020-11-03T08:02:16Z"},"accession":"S-EPMC6980756","cross_references":{"pubmed":["31706902"],"doi":["10.1016/j.jacl.2019.09.008"]}}