{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Debnath M"],"funding":["DBT/Wellcome Trust India Alliance","Wellcome Trust","Department of Science and Technology, Ministry of Science and Technology"],"pagination":["469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6981123"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["The selective transport of ions across cell membranes, controlled by membrane proteins, is critical for a living organism. DNA-based systems have emerged as promising artificial ion transporters. However, the development of stable and selective artificial ion transporters remains a formidable task. We herein delineate the construction of an artificial ionophore using a telomeric DNA G-quadruplex (h-TELO) and a lipophilic guanosine (MG). MG stabilizes h-TELO by non-covalent interactions and, along with the lipophilic side chain, promotes the insertion of h-TELO within the hydrophobic lipid membrane. Fluorescence assays, electrophysiology measurements and molecular dynamics simulations reveal that MG/h-TELO preferentially transports K<sup>+</sup>-ions in a stimuli-responsive manner. The pref"],"journal":["Nature communications"],"pubmed_title":["Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K<sup>+</sup>-ion across biological membranes."],"pmcid":["PMC6981123"],"funding_grant_id":["A/S/18/2/503986","IA/S/18/2/503986","DST/SJF/CSA-01/2015-16"],"pubmed_authors":["Chaudhuri R","Dash J","Chakraborty S","Debnath M","Jana B","Kumar YP"],"additional_accession":[]},"is_claimable":false,"name":"Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K<sup>+</sup>-ion across biological membranes.","description":"The selective transport of ions across cell membranes, controlled by membrane proteins, is critical for a living organism. DNA-based systems have emerged as promising artificial ion transporters. However, the development of stable and selective artificial ion transporters remains a formidable task. We herein delineate the construction of an artificial ionophore using a telomeric DNA G-quadruplex (h-TELO) and a lipophilic guanosine (MG). MG stabilizes h-TELO by non-covalent interactions and, along with the lipophilic side chain, promotes the insertion of h-TELO within the hydrophobic lipid membrane. Fluorescence assays, electrophysiology measurements and molecular dynamics simulations reveal that MG/h-TELO preferentially transports K<sup>+</sup>-ions in a stimuli-responsive manner. The pref","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2026-05-07T12:45:50.95Z","creation":"2020-05-22T09:02:57Z"},"accession":"S-EPMC6981123","cross_references":{"pubmed":["31980608"],"doi":["10.1038/s41467-019-13834-7"]}}