{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Londhe AD"],"funding":["American Heart Association","NIDDK NIH HHS","NHLBI NIH HHS","U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["122-125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6982540"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(2)"],"pubmed_abstract":["We have identified a molecular interaction between the reversibly oxidized form of protein tyrosine phosphatase 1B (PTP1B) and 14-3-3ζ that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3ζ and PTP1B prevented PTP1B inactivation by reactive oxygen species and decreased epidermal growth factor receptor phosphorylation. Our data suggest that destabilizing the interaction between 14-3-3ζ and the reversibly oxidized and inactive form of PTP1B may establish a path to PTP1B activation in cells."],"journal":["Nature chemical biology"],"pubmed_title":["Regulation of PTP1B activation through disruption of redox-complex formation."],"pmcid":["PMC6982540"],"funding_grant_id":["P30 CA045508","17GRNT33700265","R15 HL138605","R01 GM055989","HL138605","R01 DK124907"],"pubmed_authors":["Londhe AD","Zhang F","Kannan A","Linhardt RJ","Tonks NK","Bergeron A","Curley SM","Rivera KD","Pappin DJ","Coulis G","Rizvi SHM","Kim SJ","Boivin B"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of PTP1B activation through disruption of redox-complex formation.","description":"We have identified a molecular interaction between the reversibly oxidized form of protein tyrosine phosphatase 1B (PTP1B) and 14-3-3ζ that regulates PTP1B activity. Destabilizing the transient interaction between 14-3-3ζ and PTP1B prevented PTP1B inactivation by reactive oxygen species and decreased epidermal growth factor receptor phosphorylation. Our data suggest that destabilizing the interaction between 14-3-3ζ and the reversibly oxidized and inactive form of PTP1B may establish a path to PTP1B activation in cells.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2026-04-14T21:15:39.956Z","creation":"2020-06-26T07:04:57Z"},"accession":"S-EPMC6982540","cross_references":{"pubmed":["31873221"],"doi":["10.1038/s41589-019-0433-0"]}}