biostudies-literatureShowmaker KCNIH-NIGMSNHLBI NIH HHSNIGMS NIH HHSNIH-NHLBI56-70https://www.ebi.ac.uk/biostudies/studies/S-EPMC6985787biostudies-literatureUnknown52(1)The HSRA rat is a model of congenital abnormalities of the kidney and urogenital tract (CAKUT). Our laboratory has used this model to investigate the role of nephron number (functional unit of the kidney) in susceptibility to develop kidney disease as 50-75% offspring are born with a single kidney (HSRA-S), while 25-50% are born with two kidneys (HSRA-C). HSRA-S rats develop increased kidney injury and hypertension with age compared with nephrectomized two-kidney animals (HSRA-UNX), suggesting that even slight differences in nephron number can be an important driver in decline in kidney function. The HSRA rat was selected and inbred from a family of outbred heterogeneous stock (NIH-HS) rats that exhibited a high incidence of CAKUT. The HS model was originally developed from eight inbred stPhysiological genomicsWhole genome sequencing and novel candidate genes for CAKUT and altered nephrogenesis in the HSRA rat.PMC6985787P20GM103476P30GM103328P20GM104357P20 GM121334R01 HL137673R01HL137673P20 GM104357P20 GM103476P30 GM103328Garrett MRJohnson ACYang WCobb MBShowmaker KCfalseWhole genome sequencing and novel candidate genes for CAKUT and altered nephrogenesis in the HSRA rat.The HSRA rat is a model of congenital abnormalities of the kidney and urogenital tract (CAKUT). Our laboratory has used this model to investigate the role of nephron number (functional unit of the kidney) in susceptibility to develop kidney disease as 50-75% offspring are born with a single kidney (HSRA-S), while 25-50% are born with two kidneys (HSRA-C). HSRA-S rats develop increased kidney injury and hypertension with age compared with nephrectomized two-kidney animals (HSRA-UNX), suggesting that even slight differences in nephron number can be an important driver in decline in kidney function. The HSRA rat was selected and inbred from a family of outbred heterogeneous stock (NIH-HS) rats that exhibited a high incidence of CAKUT. The HS model was originally developed from eight inbred st2020-01-01T00:00:00Z2020 Jan2025-04-05T11:01:20.843Z2025-04-05T11:01:20.843ZS-EPMC69857873184139610.1152/physiolgenomics.00112.2019