{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song J"],"funding":["Agricultural Science and Technology Innovation Program","National Key Technology R&D Program","China Agriculture Research System"],"pagination":["skz396"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6986778"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["98(1)"],"pubmed_abstract":["We investigated the effects of inulin on intestinal barrier function and mucosal immunity in Salmonella enterica serovar Enteritidis (SE)-infected specific pathogen-free (SPF) chickens. SPF chickens (n = 240, 1-d-old) were divided into 4 groups (6 replicates per group, 10 chickens per replicate): a control group (CON) fed a basal diet without inulin supplementation and 3 SE-infected groups fed a basal diet supplemented with inulin 0% (SE group), 0.5% (0.5% InSE group), and 1% (1% InSE group), respectively. At 28 d of age, the chickens in SE-infected groups were orally infected with SE and in CON group were administrated with phosphated-buffered saline (PBS). Intestinal morphology, mucosal immunity, and intestinal barrier function-related gene expression were analyzed at 1- and 3-d post-inf"],"journal":["Journal of animal science"],"pubmed_title":["Effects of inulin supplementation on intestinal barrier function and immunity in specific pathogen-free chickens with Salmonella infection."],"pmcid":["PMC6986778"],"funding_grant_id":["ASTIPIAS04","2015BAD03B03","CARS-41","CAAS-XTCX2016010-03"],"pubmed_authors":["Wen J","Zheng M","Zhao G","Li Q","Liu R","Everaert N","Song J"],"additional_accession":[]},"is_claimable":false,"name":"Effects of inulin supplementation on intestinal barrier function and immunity in specific pathogen-free chickens with Salmonella infection.","description":"We investigated the effects of inulin on intestinal barrier function and mucosal immunity in Salmonella enterica serovar Enteritidis (SE)-infected specific pathogen-free (SPF) chickens. SPF chickens (n = 240, 1-d-old) were divided into 4 groups (6 replicates per group, 10 chickens per replicate): a control group (CON) fed a basal diet without inulin supplementation and 3 SE-infected groups fed a basal diet supplemented with inulin 0% (SE group), 0.5% (0.5% InSE group), and 1% (1% InSE group), respectively. At 28 d of age, the chickens in SE-infected groups were orally infected with SE and in CON group were administrated with phosphated-buffered saline (PBS). Intestinal morphology, mucosal immunity, and intestinal barrier function-related gene expression were analyzed at 1- and 3-d post-inf","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-04T22:27:09.243Z","creation":"2021-02-20T18:01:08Z"},"accession":"S-EPMC6986778","cross_references":{"pubmed":["31894241"],"doi":["10.1093/jas/skz396"]}}