{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weinert M"],"funding":["Imperial College London","NINDS NIH HHS"],"pagination":["8925-8934"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6988861"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["33(8)"],"pubmed_abstract":["Mitochondrial metabolic plasticity is a key adaptive mechanism in response to changes in cellular metabolic demand. Changes in mitochondrial metabolic efficiency have been linked to pathophysiological conditions, including cancer, neurodegeneration, and obesity. The ubiquitously expressed <i>DJ-1</i> (Parkinsonism-associated deglycase) is known as a Parkinson's disease gene and an oncogene. The pleiotropic functions of <i>DJ-1</i> include reactive oxygen species scavenging, RNA binding, chaperone activity, endocytosis, and modulation of major signaling pathways involved in cell survival and metabolism. Nevertheless, how these functions are linked to the role of <i>DJ-1</i> in mitochondrial plasticity is not fully understood. In this study, we describe an interaction between <i>DJ-1</i> and"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["The mitochondrial metabolic function of <i>DJ-1</i> is modulated by <i>14-3-3β</i>."],"pmcid":["PMC6988861"],"funding_grant_id":["R01 NS081746","R37 NS045876"],"pubmed_authors":["Weinert M","Alavian KN","Millet A","Jonas EA"],"additional_accession":[]},"is_claimable":false,"name":"The mitochondrial metabolic function of <i>DJ-1</i> is modulated by <i>14-3-3β</i>.","description":"Mitochondrial metabolic plasticity is a key adaptive mechanism in response to changes in cellular metabolic demand. Changes in mitochondrial metabolic efficiency have been linked to pathophysiological conditions, including cancer, neurodegeneration, and obesity. The ubiquitously expressed <i>DJ-1</i> (Parkinsonism-associated deglycase) is known as a Parkinson's disease gene and an oncogene. The pleiotropic functions of <i>DJ-1</i> include reactive oxygen species scavenging, RNA binding, chaperone activity, endocytosis, and modulation of major signaling pathways involved in cell survival and metabolism. Nevertheless, how these functions are linked to the role of <i>DJ-1</i> in mitochondrial plasticity is not fully understood. In this study, we describe an interaction between <i>DJ-1</i> and","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Aug","modification":"2025-04-05T13:37:41.975Z","creation":"2022-07-19T20:18:57.837Z"},"accession":"S-EPMC6988861","cross_references":{"pubmed":["31034784"],"doi":["10.1096/fj.201802754R","10.1096/fj.201802754r"]}}