{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["323(3)"],"submitter":["Futier E"],"pubmed_abstract":["<h4>Importance</h4>It is not known if use of colloid solutions containing hydroxyethyl starch (HES) to correct for intravascular deficits in high-risk surgical patients is either effective or safe.<h4>Objective</h4>To evaluate the effect of HES 130/0.4 compared with 0.9% saline for intravascular volume expansion on mortality and postoperative complications after major abdominal surgery.<h4>Design, setting, and participants</h4>Multicenter, double-blind, parallel-group, randomized clinical trial of 775 adult patients at increased risk of postoperative kidney injury undergoing major abdominal surgery at 20 university hospitals in France from February 2016 to July 2018; final follow-up was in October 2018.<h4>Interventions</h4>Patients were randomized to receive fluid containing either 6% HES"],"journal":["JAMA"],"pagination":["225-236"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6990683"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial."],"pmcid":["PMC6990683"],"pubmed_authors":["Samba","Mfam","Futier E","Chanques","Lebas","Dimache","Carles","Bazin JE","Wira","Deloge","Godet T","Restoux A","Garot","Burey","Cirilovic","Le Moal","Vaisse","FLASH Trial Group","Monziols","Lescot T","Allo","Napolitano","Laroche","Vignaud","Cadic A","Leone M","Jaber","De Jong","Cadic","Biais M","Velly","Asehnoune","Yves Lefrant","Jaber S","Bazin","Pottecher","Vaisse C","El Amine Y","Medam","Joannes-Boyau","Gahbiche","Huet O","Lebuffe","Beloeil","Castelli","Lescot","Dewitte A","Brandely","Paugam-Burtz C","Huet","Ouattara","Leger","Castagnoli","Feitita","Futier","Beloeil H","Paul","Venot","El Amine","Garot M","Fayon","Faucher","Lasocki","Roquilly","Cuvillon","Verzilli","Lebuffe G","Verzilli D","Defaye","Faucher M","Pereira B","Ouattara A","Asehnoune K","Begneu","Paugam-Burtz","Pastene","Rameau","Noll E","Leone","Dubout","Piriou","Le Penndu","Piriou V","Cuvillon P","Lasocki S","Restoux","Millot","Jacob"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial.","description":"<h4>Importance</h4>It is not known if use of colloid solutions containing hydroxyethyl starch (HES) to correct for intravascular deficits in high-risk surgical patients is either effective or safe.<h4>Objective</h4>To evaluate the effect of HES 130/0.4 compared with 0.9% saline for intravascular volume expansion on mortality and postoperative complications after major abdominal surgery.<h4>Design, setting, and participants</h4>Multicenter, double-blind, parallel-group, randomized clinical trial of 775 adult patients at increased risk of postoperative kidney injury undergoing major abdominal surgery at 20 university hospitals in France from February 2016 to July 2018; final follow-up was in October 2018.<h4>Interventions</h4>Patients were randomized to receive fluid containing either 6% HES","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2026-04-30T03:57:08.576Z","creation":"2020-07-31T09:16:32Z"},"accession":"S-EPMC6990683","cross_references":{"pubmed":["31961418"],"doi":["10.1001/jama.2019.20833"]}}