biostudies-literatureUnknown323(3)Futier E<h4>Importance</h4>It is not known if use of colloid solutions containing hydroxyethyl starch (HES) to correct for intravascular deficits in high-risk surgical patients is either effective or safe.<h4>Objective</h4>To evaluate the effect of HES 130/0.4 compared with 0.9% saline for intravascular volume expansion on mortality and postoperative complications after major abdominal surgery.<h4>Design, setting, and participants</h4>Multicenter, double-blind, parallel-group, randomized clinical trial of 775 adult patients at increased risk of postoperative kidney injury undergoing major abdominal surgery at 20 university hospitals in France from February 2016 to July 2018; final follow-up was in October 2018.<h4>Interventions</h4>Patients were randomized to receive fluid containing either 6% HESJAMA225-236https://www.ebi.ac.uk/biostudies/studies/S-EPMC6990683biostudies-literatureEffect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial.PMC6990683SambaMfamFutier EChanquesLebasDimacheCarlesBazin JEWiraDelogeGodet TRestoux AGarotBureyCirilovicLe MoalVaisseFLASH Trial GroupMonziolsLescot TAlloNapolitanoLarocheVignaudCadic ALeone MJaberDe JongCadicBiais MVellyAsehnouneYves LefrantJaber SBazinPottecherVaisse CEl Amine YMedamJoannes-BoyauGahbicheHuet OLebuffeBeloeilCastelliLescotDewitte ABrandelyPaugam-Burtz CHuetOuattaraLegerCastagnoliFeititaFutierBeloeil HPaulVenotEl AmineGarot MFayonFaucherLasockiRoquillyCuvillonVerzilliLebuffe GVerzilli DDefayeFaucher MPereira BOuattara AAsehnoune KBegneuPaugam-BurtzPasteneRameauNoll ELeoneDuboutPiriouLe PennduPiriou VCuvillon PLasocki SRestouxMillotJacobfalseEffect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial.<h4>Importance</h4>It is not known if use of colloid solutions containing hydroxyethyl starch (HES) to correct for intravascular deficits in high-risk surgical patients is either effective or safe.<h4>Objective</h4>To evaluate the effect of HES 130/0.4 compared with 0.9% saline for intravascular volume expansion on mortality and postoperative complications after major abdominal surgery.<h4>Design, setting, and participants</h4>Multicenter, double-blind, parallel-group, randomized clinical trial of 775 adult patients at increased risk of postoperative kidney injury undergoing major abdominal surgery at 20 university hospitals in France from February 2016 to July 2018; final follow-up was in October 2018.<h4>Interventions</h4>Patients were randomized to receive fluid containing either 6% HES2020-01-01T00:00:00Z2020 Jan2026-04-30T03:57:08.576Z2020-07-31T09:16:32ZS-EPMC69906833196141810.1001/jama.2019.20833