{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["323(3)"],"submitter":["Matta MK"],"pubmed_abstract":["<h4>Importance</h4>A prior pilot study demonstrated the systemic absorption of 4 sunscreen active ingredients; additional studies are needed to determine the systemic absorption of additional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recommended by the US Food and Drug Administration (FDA).<h4>Objective</h4>To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in 4 sunscreen products under single- and maximal-use conditions.<h4>Design, setting, and participants</h4>Randomized clinical trial at a clinical pharmacology unit (West Bend, Wisconsin) was conducted in 48 healthy participants. The study was conducted between January and February 2019.<h4>Interv"],"journal":["JAMA"],"pagination":["256-267"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6990686"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial."],"pmcid":["PMC6990686"],"pubmed_authors":["Oh L","Bashaw E","Sanabria C","Michele T","Adah S","Zusterzeel R","Matta MK","Volpe DA","Ganley C","Patel V","Pilli NR","Kemp S","Godfrey A","Wang J","Zineh I","Florian J","Yang Y","Coelho S","Strauss DG","Furlong LA"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.","description":"<h4>Importance</h4>A prior pilot study demonstrated the systemic absorption of 4 sunscreen active ingredients; additional studies are needed to determine the systemic absorption of additional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recommended by the US Food and Drug Administration (FDA).<h4>Objective</h4>To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in 4 sunscreen products under single- and maximal-use conditions.<h4>Design, setting, and participants</h4>Randomized clinical trial at a clinical pharmacology unit (West Bend, Wisconsin) was conducted in 48 healthy participants. The study was conducted between January and February 2019.<h4>Interv","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2026-04-30T02:15:13.079Z","creation":"2020-07-31T09:16:31Z"},"accession":"S-EPMC6990686","cross_references":{"pubmed":["31961417"],"doi":["10.1001/jama.2019.20747"]}}