biostudies-literatureUnknown323(3)Matta MK<h4>Importance</h4>A prior pilot study demonstrated the systemic absorption of 4 sunscreen active ingredients; additional studies are needed to determine the systemic absorption of additional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recommended by the US Food and Drug Administration (FDA).<h4>Objective</h4>To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in 4 sunscreen products under single- and maximal-use conditions.<h4>Design, setting, and participants</h4>Randomized clinical trial at a clinical pharmacology unit (West Bend, Wisconsin) was conducted in 48 healthy participants. The study was conducted between January and February 2019.<h4>IntervJAMA256-267https://www.ebi.ac.uk/biostudies/studies/S-EPMC6990686biostudies-literatureEffect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.PMC6990686Oh LBashaw ESanabria CMichele TAdah SZusterzeel RMatta MKVolpe DAGanley CPatel VPilli NRKemp SGodfrey AWang JZineh IFlorian JYang YCoelho SStrauss DGFurlong LAfalseEffect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial.<h4>Importance</h4>A prior pilot study demonstrated the systemic absorption of 4 sunscreen active ingredients; additional studies are needed to determine the systemic absorption of additional active ingredients and how quickly systemic exposure exceeds 0.5 ng/mL as recommended by the US Food and Drug Administration (FDA).<h4>Objective</h4>To assess the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in 4 sunscreen products under single- and maximal-use conditions.<h4>Design, setting, and participants</h4>Randomized clinical trial at a clinical pharmacology unit (West Bend, Wisconsin) was conducted in 48 healthy participants. The study was conducted between January and February 2019.<h4>Interv2020-01-01T00:00:00Z2020 Jan2026-04-30T02:15:13.079Z2020-07-31T09:16:31ZS-EPMC69906863196141710.1001/jama.2019.20747