{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao LP"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS","NIMH NIH HHS"],"pagination":["e0226803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6992005"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>HIV vaccine trials routinely measure multiple vaccine-elicited immune responses to compare regimens and study their potential associations with protection. Here we employ unsupervised learning tools facilitated by a bidirectional power transformation to explore the multivariate binding antibody and T-cell response patterns of immune responses elicited by two pox-protein HIV vaccine regimens. Both regimens utilized a recombinant canarypox vector (ALVAC-HIV) prime and a bivalent recombinant HIV-1 Envelope glycoprotein 120 subunit boost. We hypothesized that within each trial, there were participant subgroups sharing similar immune responses and that their frequencies differed across trials.<h4>Methods and findings</h4>We analyzed data from three trials-RV144 (NCT00223080),"],"journal":["PloS one"],"pubmed_title":["Landscapes of binding antibody and T-cell responses to pox-protein HIV vaccines in Thais and South Africans."],"pmcid":["PMC6992005"],"funding_grant_id":["UM1 AI069469","UM1AI068618","UM1 AI068635","R21 MH083308","UM1AI068614","UM1 AI068614","R01 AI122991","UM1AI068635","R37 AI054165","UM1 AI068618","UM1 AI069453"],"pubmed_authors":["Innes C","Moodie Z","Rerks-Ngarm S","Rouphael N","Zhao M","Janes HE","Pitisuttithum P","Fong Y","Zhao LP","Cohen KW","McElrath MJ","Fiore-Gartland A","Yates NL","Dintwe O","Gilbert PB","Lazarus E","Corey L","Gray GE","Frahm N","Fleurs L","Seaton KE","Huang Y","De Rosa SC","Garrett N","Robb ML","Nitayaphan S","Michael NL","Tomaras GD","Carpp LN"],"additional_accession":[]},"is_claimable":false,"name":"Landscapes of binding antibody and T-cell responses to pox-protein HIV vaccines in Thais and South Africans.","description":"<h4>Background</h4>HIV vaccine trials routinely measure multiple vaccine-elicited immune responses to compare regimens and study their potential associations with protection. Here we employ unsupervised learning tools facilitated by a bidirectional power transformation to explore the multivariate binding antibody and T-cell response patterns of immune responses elicited by two pox-protein HIV vaccine regimens. Both regimens utilized a recombinant canarypox vector (ALVAC-HIV) prime and a bivalent recombinant HIV-1 Envelope glycoprotein 120 subunit boost. We hypothesized that within each trial, there were participant subgroups sharing similar immune responses and that their frequencies differed across trials.<h4>Methods and findings</h4>We analyzed data from three trials-RV144 (NCT00223080),","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-05-07T21:58:26.858Z","creation":"2020-05-22T10:36:10Z"},"accession":"S-EPMC6992005","cross_references":{"pubmed":["31999736"],"doi":["10.1371/journal.pone.0226803"]}}