{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fu SS"],"funding":["National Key R&amp;D Program of China","Natural Science Foundation of Tianjin City","111 Project","National Natural Science Foundation of China"],"pagination":["100793"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6992937"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Quinolones and isoquinolones are of interest to pharmaceutical industry owing to their potent biological activities. Herein, we first encapsulated sub-nm Pt nanoclusters into Zr-porphyrin frameworks to afford an efficient photocatalyst Pt<sub>0.9</sub>@PCN-221. This catalyst can dramatically promote electron-hole separation and <sup>1</sup>O<sub>2</sub> generation to achieve synergistic effect first in the metal-organic framework (MOF) system, leading to the highest activity in photosynthesis of (iso)quinolones in >90.0% yields without any electronic sacrificial agents. Impressively, Pt<sub>0.9</sub>@PCN-221 was reused 10 times without loss of activity and can catalyze gram-scale synthesis of 1-methyl-5-nitroisoquinolinone at an activity of 175.8 g·g<sub>cat</sub><sup>-1</sup>, 22 times hi"],"journal":["iScience"],"pubmed_title":["Synergistic Effect over Sub-nm Pt Nanocluster@MOFs Significantly Boosts Photo-oxidation of N-alkyl(iso)quinolinium Salts."],"pmcid":["PMC6992937"],"funding_grant_id":["18JCJQJC47700","21671032","21722104","17JCQNJC05100","21703155","18JCQNJC76500","D17003","2017YFA0700104"],"pubmed_authors":["Fu SS","Lu TB","Zhang ZM","Lin W","Ren XY","Guo S","Lan G"],"additional_accession":[]},"is_claimable":false,"name":"Synergistic Effect over Sub-nm Pt Nanocluster@MOFs Significantly Boosts Photo-oxidation of N-alkyl(iso)quinolinium Salts.","description":"Quinolones and isoquinolones are of interest to pharmaceutical industry owing to their potent biological activities. Herein, we first encapsulated sub-nm Pt nanoclusters into Zr-porphyrin frameworks to afford an efficient photocatalyst Pt<sub>0.9</sub>@PCN-221. This catalyst can dramatically promote electron-hole separation and <sup>1</sup>O<sub>2</sub> generation to achieve synergistic effect first in the metal-organic framework (MOF) system, leading to the highest activity in photosynthesis of (iso)quinolones in >90.0% yields without any electronic sacrificial agents. Impressively, Pt<sub>0.9</sub>@PCN-221 was reused 10 times without loss of activity and can catalyze gram-scale synthesis of 1-methyl-5-nitroisoquinolinone at an activity of 175.8 g·g<sub>cat</sub><sup>-1</sup>, 22 times hi","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-05-29T21:02:06.599Z","creation":"2025-05-29T21:02:06.599Z"},"accession":"S-EPMC6992937","cross_references":{"pubmed":["31958757"],"doi":["10.1016/j.isci.2019.100793"]}}