biostudies-literatureFu SSNational Key R&D Program of ChinaNatural Science Foundation of Tianjin City111 ProjectNational Natural Science Foundation of China100793https://www.ebi.ac.uk/biostudies/studies/S-EPMC6992937biostudies-literatureUnknown23(1)Quinolones and isoquinolones are of interest to pharmaceutical industry owing to their potent biological activities. Herein, we first encapsulated sub-nm Pt nanoclusters into Zr-porphyrin frameworks to afford an efficient photocatalyst Pt_0.9@PCN-221. This catalyst can dramatically promote electron-hole separation and ¹O₂ generation to achieve synergistic effect first in the metal-organic framework (MOF) system, leading to the highest activity in photosynthesis of (iso)quinolones in >90.0% yields without any electronic sacrificial agents. Impressively, Pt_0.9@PCN-221 was reused 10 times without loss of activity and can catalyze gram-scale synthesis of 1-methyl-5-nitroisoquinolinone at an activity of 175.8 g·g_cat^-1, 22 times hiiScienceSynergistic Effect over Sub-nm Pt Nanocluster@MOFs Significantly Boosts Photo-oxidation of N-alkyl(iso)quinolinium Salts.PMC699293718JCJQJC47700216710322172210417JCQNJC051002170315518JCQNJC76500D170032017YFA0700104Fu SSLu TBZhang ZMLin WRen XYGuo SLan GfalseSynergistic Effect over Sub-nm Pt Nanocluster@MOFs Significantly Boosts Photo-oxidation of N-alkyl(iso)quinolinium Salts.Quinolones and isoquinolones are of interest to pharmaceutical industry owing to their potent biological activities. Herein, we first encapsulated sub-nm Pt nanoclusters into Zr-porphyrin frameworks to afford an efficient photocatalyst Pt_0.9@PCN-221. This catalyst can dramatically promote electron-hole separation and ¹O₂ generation to achieve synergistic effect first in the metal-organic framework (MOF) system, leading to the highest activity in photosynthesis of (iso)quinolones in >90.0% yields without any electronic sacrificial agents. Impressively, Pt_0.9@PCN-221 was reused 10 times without loss of activity and can catalyze gram-scale synthesis of 1-methyl-5-nitroisoquinolinone at an activity of 175.8 g·g_cat^-1, 22 times hi2020-01-01T00:00:00Z2020 Jan2025-05-29T21:02:06.599Z2025-05-29T21:02:06.599ZS-EPMC69929373195875710.1016/j.isci.2019.100793