{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kallupi M"],"funding":["NIDA NIH HHS","HHS | NIH | National Institute on Drug Abuse"],"pagination":["2140-2148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6994987"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117(4)"],"pubmed_abstract":["Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the development of addiction-like behaviors in some but not all individuals are poorly known. To address this issue, we used a unique outbred rat population (heterogeneous stock) that better models the behavioral and genetic diversity that is found in humans. We characterized individual differences in addiction-like behaviors using an addiction index that incorporates the key criteria of opioid use disorder: escalated intake, highly motivated responding, and hyperalgesia. Using in vitro electrophysiological recordings in the central nucleus of the am"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats."],"pmcid":["PMC6994987"],"funding_grant_id":["P50 DA037844","U01 DA043799","DA043799","U01 DA044451","DA044451"],"pubmed_authors":["Solberg Woods LC","Kallupi M","Kononoff J","George O","Palmer AA","Carrette LLG","Schweitzer P","de Guglielmo G"],"additional_accession":[]},"is_claimable":false,"name":"Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats.","description":"Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the development of addiction-like behaviors in some but not all individuals are poorly known. To address this issue, we used a unique outbred rat population (heterogeneous stock) that better models the behavioral and genetic diversity that is found in humans. We characterized individual differences in addiction-like behaviors using an addiction index that incorporates the key criteria of opioid use disorder: escalated intake, highly motivated responding, and hyperalgesia. Using in vitro electrophysiological recordings in the central nucleus of the am","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jan","modification":"2025-04-04T14:59:29.355Z","creation":"2025-04-04T14:59:29.355Z"},"accession":"S-EPMC6994987","cross_references":{"pubmed":["31932450"],"doi":["10.1073/pnas.1915143117"]}}