{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin YL"],"funding":["Health Science Promotion Project of Beijing; Beijing Natural Science Foundation","Special Fund for the Capital Characteristic Clinical Medicine Development Project","Beijing Municipal Administration of Hospitals’ Ascent Plan","Beijing Municipal Grant for Medical Talents Group on Peritoneal Surface Oncology"],"pagination":["1104-1114"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6997068"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["<h4>Background</h4>Pseudomyxoma peritonei (PMP) is an indolent malignancy and insensitive to systemic chemotherapy. The authors established patient-derived xenograft (PDX) model of PMP, and evaluated the efficacy and toxicity of intraperitoneal (i.p.) administration of 5-fluorouracil (5-FU) in this model.<h4>Methods</h4>Human PMP sample was collected to establish subcutaneous (s.c.) and i.p.<h4>Model</h4>In vivo study of i.p. injection of 5-FU was performed in i.p. model, with experimental peritoneal cancer index (ePCI) score and pathological examinations for evaluating the efficacy and toxicity.<h4>Results</h4>Both s.c. and i.p. models were constructed. The average passage interval of s.c. model was 44.2 ± 5.2 days, and the i.p. model was characterized by disseminated solid tumor nodules "],"journal":["Cancer medicine"],"pubmed_title":["Establishment of patient-derived xenograft model of peritoneal mucinous carcinomatosis with signet ring cells and in vivo study on the efficacy and toxicity of intraperitoneal injection of 5-fluorouracil."],"pmcid":["PMC6997068"],"funding_grant_id":["2017400003235J007","DFL20180701","7172108","Z161100000516077"],"pubmed_authors":["Xu HB","Ma R","Chen Q","Li Y","Zhang J","Jiang X","Lin YL","Yang ZR","Peng Z","Yan FC"],"additional_accession":[]},"is_claimable":false,"name":"Establishment of patient-derived xenograft model of peritoneal mucinous carcinomatosis with signet ring cells and in vivo study on the efficacy and toxicity of intraperitoneal injection of 5-fluorouracil.","description":"<h4>Background</h4>Pseudomyxoma peritonei (PMP) is an indolent malignancy and insensitive to systemic chemotherapy. The authors established patient-derived xenograft (PDX) model of PMP, and evaluated the efficacy and toxicity of intraperitoneal (i.p.) administration of 5-fluorouracil (5-FU) in this model.<h4>Methods</h4>Human PMP sample was collected to establish subcutaneous (s.c.) and i.p.<h4>Model</h4>In vivo study of i.p. injection of 5-FU was performed in i.p. model, with experimental peritoneal cancer index (ePCI) score and pathological examinations for evaluating the efficacy and toxicity.<h4>Results</h4>Both s.c. and i.p. models were constructed. The average passage interval of s.c. model was 44.2 ± 5.2 days, and the i.p. model was characterized by disseminated solid tumor nodules ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-05-31T23:16:29.826Z","creation":"2021-02-19T11:40:52Z"},"accession":"S-EPMC6997068","cross_references":{"pubmed":["31814323"],"doi":["10.1002/cam4.2766"]}}