{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Reiman EM"],"funding":["Rosetrees Trust","NCATS NIH HHS","NIA NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Aging","Alzheimers Research UK","Medical Research Council","Parkinson's UK"],"pagination":["667"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6997393"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer's dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically characterized Alzheimer's dementia cases and controls. APOE2/2 was associated with a low Alzheimer's dementia odds ratios compared to APOE2/3 and 3/3, and an exceptionally low odds ratio compared to APOE4/4, and the impact of APOE2 and APOE4 gene dose was significantly greater in the neuropathologically confirmed group than in more than 24,000 neuropathologically unconfirmed cases and cont"],"journal":["Nature communications"],"pubmed_title":["Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study."],"pmcid":["PMC6997393"],"funding_grant_id":["R01 AG015819","ART-PG2010-1","ARUK-EG2014A-1","R01 AG030653","P30 AG010133","P01 AG019724","M733","U01 AG046139","P30 AG062715","ART-PPG2009A-1","MR/N026004/1","ARUK-PhD2014-16","P30 AG066462","RF1 AG057902","RF1 AG054023","P30 AG019610","R01 AG064877","U01 AG058922","P50 AG008702","RF1 AG015473","P30 AG010124","P30 AG062421","P50 AG005136","MR/L501542/1","P30 AG010161","RF1 AG051504","UL1 TR002369","G0701075","P30 AG062429","G-0907","UKDRI-1009","ART-PPG2011A-14","R01 AG061796","U01 AG032984","U24 AG056270","R01 AG017917","G0901254","RF1AG057519, P30-AG10161, R01AG15819, R01AG17917"],"pubmed_authors":["Peskind E","O'Bryant S","Kauwe JSK","Carrasquillo MM","Lunetta KL","Carney RM","Rosen HJ","McKee AC","Pierce A","Bowen JD","DeCarli C","Su Y","Jin LW","Larson EB","Rogaeva E","Rosenberg RN","Stern RA","Duara R","Martiniuk F","Kramer JH","Younkin SG","Sano M","Schneider JA","Wu CK","Boxer A","Lah JJ","Galasko DR","Seeley WW","Potter H","Yu L","Van Deerlin VM","Cao C","Smith AG","Zhao Y","Katz MJ","Reisch JS","Tsuang DW","Tanzi RE","Jarvik GP","Boeve BF","Asthana S","Growdon JH","Weintraub S","Albert MS","Cantwell LB","Barber RC","Burns JM","Kunkle BW","Malamon J","Mesulam M","Beach TG","Woltjer RL","Keene CD","Huentelman MJ","Apostolova LG","Kowall NW","Kuzma AP","Trojanowski JQ","Reitz C","Swerdlow RH","Kukull WA","Caselli RJ","Evans DA","Crocco EA","Chen Y","Reisberg B","Green RC","Ringman JM","Reiman EM","LaFerla FM","Li G","Crane PK","Wang LS","Foroud T","Becker JT","Carlsson CM","Petersen RC","Beecham GW","Abner E","Hakonarson H","Lyketsos CG","Cribbs DH","Fardo DW","Barral S","Van Eldik LJ","Fallon KB","Miller BL","Bigio EH","Kaye JA","Arboleda-Velasquez JF","Paulson HL","Paul Vonsattel J","Buxbaum JD","McCurry SM","Miller CA","Honig LS","Baldwin CT","Goate AM","Yu CE","De Jager PL","Saykin AJ","Faber KM","Harrell LE","Quinn JF","Kofler JK","Lipton RB","Welsh-Bohmer KA","Chui HC","Hyman BT","Gilbert JR","Huebinger RM","Lieberman AP","Martin ER","Sager MA","Schellenberg GD","Spina S","Pericak-Vance MA","Valladares O","Blacker D","Karydas A","Ghisays V","Masliah E","Vardarajan BN","Royall DR","Jun GR","Hulette CM","Burke JR","Wilhelmsen KC","Adams PM","Cruchaga C","Atwood CS","Hamilton-Nelson KL","Mukherjee S","Cairns NJ","Dick M","Naj AC","Roberson ED","Qu L","McDonough S","Sonnen JA","Beekly D","Marson DC","Kim R","Bennett DA","Kamboh MI","Arnold SE","Hamilton RL","Albin RL","Dickson DW","Fairchild TJ","Farlow MR","Vinters HV","Lopez OL","Olichney JM","Graff-Radford NR","Myers AJ","Ghetti BF","George-Hyslop PS","Farrer LA","McCormick WC","Wright CB","Duque L","Mayeux RP","Poon WW","Mash DC","Ertekin-Taner N","Barnes LL","Hardy J","McDavid AN","Miller JW","Haines JL","Doody RS","Gwirtsman HE","Gearing M","Parisi JE","Troncoso JC","Ferris S","Leverenz JB","Alzheimer’s Disease Genetics Consortium","Frosch MP","Geschwind DH","Williamson J","Schneider LS","Levey AI","Bird TD","Raj A","Morris JC","Carlson CS","Wingo TS","Quiroz YT","Leung YY","Montine TJ","Raskind M"],"additional_accession":[]},"is_claimable":false,"name":"Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.","description":"Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer's dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically characterized Alzheimer's dementia cases and controls. APOE2/2 was associated with a low Alzheimer's dementia odds ratios compared to APOE2/3 and 3/3, and an exceptionally low odds ratio compared to APOE4/4, and the impact of APOE2 and APOE4 gene dose was significantly greater in the neuropathologically confirmed group than in more than 24,000 neuropathologically unconfirmed cases and cont","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Feb","modification":"2025-04-04T22:29:53.931Z","creation":"2020-05-22T09:35:42Z"},"accession":"S-EPMC6997393","cross_references":{"pubmed":["32015339"],"doi":["10.1038/s41467-019-14279-8"]}}